7409-31-6Relevant academic research and scientific papers
A novel one-pot approach to oxidative aromatization and bromination of pyrazolidin-3-one with HBr-H2O2 system
Yang, Shanguang,Liu, Jingjing,Jin, Zhudan,Tian, Wei,Sun, Hao,Wang, Mingliang
, p. 165 - 169 (2018/05/26)
An efficient and green one-pot method for the oxidative aromatization and bromination of pyrazolidin-3-ones under mild conditions with a HBr-H2O2 system was developed. A mechanism was proposed.
DMF-catalyzed direct and regioselective C-H functionalization: Electrophilic/nucleophilic 4-halogenation of 3-oxypyrazoles
Liu, Yuanyuan,He, Guangke,Chen, Kai,Jin, Yin,Li, Yufeng,Zhu, Hongjun
experimental part, p. 5323 - 5330 (2011/11/13)
A novel, straightforward, and highly regioselective 4-chlorination of 3-oxypyrazole derivatives in boiling thionyl chloride (SOCl2) in the presence of catalytic N,N-dimethylformamide (DMF) has been developed. This reaction likely proceeds through a DMF-catalyzed electrophilic/nucleophilic chlorination mechanism and involves electrophilic attack by SOCl2 and nucleophilic substitution by Cl- as the key steps. Based on this mechanism, the corresponding 4-bromination and 4-iodination of 3-oxypyrazoles have also been achieved in good yield by adding Br- and I -, respectively, to the reaction system. This halogenation method enables quick access to many original 4-halo-3-oxypyrazole series. A novel DMF-catalyzed electrophilic/nucleophilic 4-halogenation of 3-oxypyrazole derivatives has been developed. This halogenation procedure provides quick access to many novel 4-halo-3-oxypyrazole series.
Synthesis of 3-substituted 1-phenyl-1H-pyrazole-4-carbaldehydes and the corresponding ethanones by Pd-catalysed cross-coupling reactions
Arbaciauskiene, Egle,Martynaitis, Vytas,Krikstolaityte, Sonata,Holzer, Wolfgang,Sackus, Algirdas
scheme or table, p. 1 - 21 (2012/02/04)
An efficient synthetic route to construct ortho-substituted 1-phenyl-1H-pyrazole-4-carboxaldehydes and the corresponding ethanones starting from 1-phenyl-1H-pyrazol-3-ol is described. Carbon-carbon bond-forming Pd-catalysed cross-coupling reactions were applied for the functionalisation of the intermediate pyrazole triflates. Detailed NMR spectroscopic investigations were undertaken with all obtained products. ARKAT-USA, Inc.
Pd-catalyzed cross-coupling reactions of halogenated 1-phenylpyrazol-3-ols and related triflates
Arba?iauskiene, Egle,Vilkauskaite, Gyte,Eller, Gernot A.,Holzer, Wolfgang,?a?kus, Algirdas
scheme or table, p. 7817 - 7824 (2009/12/26)
1-Phenyl-1H-pyrazol-3-ol was used as a versatile synthon for the preparation of various 1-phenyl-1H-pyrazole derivatives substituted at C-3 and C-4 of the pyrazole nucleus and at the phenyl ring para-position. Treatment of 1-phenyl-1H-pyrazol-3-ol with tr
