74104-12-4Relevant academic research and scientific papers
Revisit to the reduction of allylic chlorides to less substituted olefins by a low-valent chromium species in the presence of a proton source
Omoto, Mineko,Kato, Nobuo,Sogon, Tetsuya,Mori, Akira
, p. 939 - 941 (2007/10/03)
Allylic chlorides have been reduced to afford less substituted olefins by a low-valent chromium species in the presence of an alcoholic proton source. This process certainly has synthetic benefits since the regio-selectivity of the reduction is high and the reaction conditions are mild and nearly neutral.
Elimination Reactions of Terminal β-Oxy Selenoxides. Synthesis of Aryl and Vinyl Enol Ethers and of Furans, Oxazoles, and Thiazoles
Tiecco, Marcello,Testaferri, Lorenzo,Tingoli, Marco,Marini, Francesca
, p. 1349 - 1354 (2007/10/02)
Elimination reactions of terminal selenoxides holding an alkoxy group in the β-position, RCH(OR)CH2SeOPh, are usually difficult and can give rise to complex reaction mixtures.We report that these reactions take place more easily whenever the oxygen atom is linked to an unsaturated group (-CH=CHR, -Ar, -CR=O, -CH=NR).These selenoxides are easily available, and the elimination reaction was employed to effect useful syntheses of both open-chain and cyclic aryl and vinyl enol ethers.Moreover, by simple isomerization with acids or bases the cyclic derivatives can be transformed into the corresponding furans.The same procedure has been employed to synthesize substituted oxazoles and thiazoles also.
Carbonyl Methylenation Using a Titanium- Aluminum (Tebbe) Complex
Pine, Stanley H.,Pettit, Robert J.,Geib, Gregory D.,Cruz, Susana G.,Gallego, Claudio H.,et al.
, p. 1212 - 1216 (2007/10/02)
The titanium-aluminum (Tebbe) complex is shown to be an effective methylenating agent for a variety of carbonyl groups.The reaction is unique in that the carbonyl groups of carboxylic acid derivatives are readily methylenated.Thus vinyl enol ethers are prepared from esters and enamines are formed from amides.The complex provides a method for methylenating hindered or base sensitive ketones that is advantageous to the Wittig reagent.Selective methylenation of dicarbonyl compounds is also accomplished.
