74106-81-3

Basic information

• Product Name: Ethyl 2,2-Difluorohexanoate
• Synonyms: Ethyl 2,2-Difluorohexanoate;2,2-DIFLUOROHEXANOIC ACID ETHYL ESTER;HEXANOIC ACID, 2,2-DIFLUORO-, ETHYL ESTER;2,2-Difluorhexanoic acid ethyl ester;Ethyl 2,2-difluorocaproate
• CAS NO: 74106-81-3
• Molecular Formula: C₈H₁₄F₂O₂
• Molecular Weight: 180.1924
• Mol File: 74106-81-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 172℃
• Flash Point: 57℃
• Appearance: /
• Density: 1.029
• Vapor Pressure: 1.357mmHg at 25°C
• Refractive Index: 1.387
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Ethyl 2,2-Difluorohexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2,2-Difluorohexanoate(74106-81-3)
• EPA Substance Registry System: Ethyl 2,2-Difluorohexanoate(74106-81-3)

Safety Data

• Hazardous Substances Data: 74106-81-3(Hazardous Substances Data)

Usage

Uses

Ethyl 2,2-Difluorohexanoate is used as a reactant in the preparation of lubiprostone.

Synthesis Reference(s)

The Journal of Organic Chemistry, 57, p. 5144, 1992 DOI: 10.1021/jo00045a027

InChI:InChI=1/C8H14F2O2/c1-3-5-6-8(9,10)7(11)12-4-2/h3-6H2,1-2H3

Upstream product

• 106-98-9 1-butylene 
• 667-27-6 Ethyl bromodifluoroacetate 
• 212768-75-7 2-(4-methoxy-phenylsulfanyl)-hexanoic acid ethyl ester 
• 615-96-3 Ethyl 2-bromohexanoate 
• 5753-96-8 ethyl 2-oxohexanoate 
• 7648-30-8 ethyl 2,2-difluoro-2-iodoacetate 

Downstream Products

• 74106-82-4 Dimethyl-(2-oxo-3,4-difluoroheptyl)phosphonate 
• 50889-46-8 dimethyl (3,3-difluoro-2-oxoheptyl)-phosphonate 
• 333963-40-9 lubiprostone 

Relevant articles and documents

XANOMELINE DERIVATIVES AND METHODS FOR TREATING NEUROLOGICAL DISORDERS

Provided herein are compounds comprising compounds of formula (I) and/or salts thereof; wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine, and the remainder are independently chosen from hydrogen and fluorine; and R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 are independently chosen from hydrogen and deuterium; with the proviso that when R1, R2, and R3 are fluorine, then at least one of R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine or at least one of R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23is deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.

Synthesis of 2, 2 - [...] acid ethyl ester method (by machine translation)

The invention relates to a method for synthesizing 2, 2 - [...] acid ethyl ester method, the glass in the reaction container, adding benzoin two thioether and 2, 6 - dimethyl - 1, 4 - dihydro - 3, 5 - pyridine dicarboxylic acid diethyl, replace the nitrogen glass after the air in the reaction container, adding butene and bromine two fluorine ethyl acetate, then adding solvent; the glass reaction container is placed on a blue light LED lamp or white light energy-saving lamp irradiation under 12 - 48 h, then remove the product in the solvent, adding petroleum ether product dissolved, adopts the 300 - 400 mesh silica gel as the stationary phase of column chromatography technology, wet in france type, in order to petroleum ether as eluent to elute, GC - MS detection product belt, and the collected [...] turns on lathe does, to get the. The method is simple in operation, solvent to the low quality requirement, can be corresponding to the multi-olefin, raw materials are easy, low cost, mild reaction conditions, and adopts a non-metal catalytic, preventing the metal residue. (by machine translation)

Process for Preparing Lubiprostone and Intermediate Therefor

The present invention relates to a method for producing lubiprostone and an intermediate product used therefor. According to the present invention, the selective introduction of a protecting group onto corey lactone diol enables the production of lubiprostone in an efficient and economical way.