SKF₈₃₈₂₂ hydrobromide, also known as N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide, is a potent agonist of peripheral dopamine receptors. It is a hydrobromide salt prepared from the corresponding base and one equivalent of hydrogen bromide. SKF₈₃₈₂₂ hydrobromide exhibits high affinity and selectivity for dopamine D1-like receptor agonist, with Ki values ranging from 3.2 to 1385 nM at various recombinant receptors. SKF₈₃₈₂₂ hydrobromide stimulates adenylyl cyclase with an EC50 of 65 nM and is known to induce extreme arousal and hyperlocomotion in monkeys following subcutaneous administration.

74115-10-9

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Basic information
1. Product Name: SKF₈₃₈₂₂ hydrobromide
2. Synonyms: SKF₈₃₈₂₂ hydrobromide
3. CAS NO:74115-10-9
4. Molecular Formula:
5. Molecular Weight: 424.765
6. EINECS: N/A
7. Product Categories: N/A
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: N/A
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: N/A
9. CAS DataBase Reference: SKF₈₃₈₂₂ hydrobromide(CAS DataBase Reference)
10. NIST Chemistry Reference: SKF₈₃₈₂₂ hydrobromide(74115-10-9)
11. EPA Substance Registry System: SKF₈₃₈₂₂ hydrobromide(74115-10-9)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 74115-10-9(Hazardous Substances Data)

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74115-10-9 Usage

Uses

1. Used in Pharmaceutical Research:
SKF₈₃₈₂₂ hydrobromide is used as a research tool for studying the role of dopamine receptors in various physiological and pathological processes. Its high affinity and selectivity for dopamine D1-like receptors make it a valuable compound for investigating the mechanisms of dopamine signaling and its implications in different diseases.
2. Used in Neuropharmacology:
In the field of neuropharmacology, SKF₈₃₈₂₂ hydrobromide is used as a selective agonist to explore the effects of dopamine on the central nervous system. This application helps researchers understand the role of dopamine in modulating various cognitive and motor functions, as well as its involvement in neuropsychiatric disorders such as schizophrenia, Parkinson's disease, and addiction.
3. Used in Drug Development:
SKF₈₃₈₂₂ hydrobromide is utilized in the development of novel therapeutic agents targeting dopamine receptors. Its agonistic properties can be leveraged to design drugs that modulate dopamine signaling, potentially leading to treatments for various neurological and psychiatric conditions.
4. Used in Preclinical Studies:
In preclinical research, SKF₈₃₈₂₂ hydrobromide is employed to evaluate the potential therapeutic effects of dopamine receptor agonists in animal models. This application aids in assessing the safety, efficacy, and pharmacokinetic properties of new compounds before they proceed to clinical trials.
5. Used in Drug Delivery Systems:
Similar to gallotannin, SKF₈₃₈₂₂ hydrobromide can also be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Various organic and metallic nanoparticles can be employed as carriers for SKF₈₃₈₂₂ hydrobromide, aiming to improve its overall effectiveness in targeting dopamine receptors.

Check Digit Verification of cas no

The CAS Registry Mumber 74115-10-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,1,1 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 74115-10:
(7*7)+(6*4)+(5*1)+(4*1)+(3*5)+(2*1)+(1*0)=99
99 % 10 = 9
So 74115-10-9 is a valid CAS Registry Number.

74115-10-9 Well-known Company Product Price

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Sigma
(SML0513) SKF83822 hydrobromide
74115-10-9
SML0513-5MG
1,148.94CNY
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Sigma
(SML0513) SKF83822 hydrobromide
74115-10-9
SML0513-25MG
4,630.86CNY
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