74124-11-1

Basic information

• Product Name: Acetamide, N-[4-amino-5-(4-chlorophenyl)-6-ethyl-2-pyrimidinyl]-
• CAS NO: 74124-11-1
• Molecular Formula: C14H15ClN4O
• Molecular Weight: 290.752
• Mol File: 74124-11-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-amino-5-(4-chlorophenyl)-6-ethyl-2-pyrimidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-amino-5-(4-chlorophenyl)-6-ethyl-2-pyrimidinyl]-(74124-11-1)
• EPA Substance Registry System: Acetamide, N-[4-amino-5-(4-chlorophenyl)-6-ethyl-2-pyrimidinyl]-(74124-11-1)

Safety Data

• Hazardous Substances Data: 74124-11-1(Hazardous Substances Data)

Upstream product

• 143947-41-5 C₂₆H₂₁ClN₄O₂ 
• 143947-40-4 N-[5-(4-Chloro-phenyl)-2-(2,2-dimethyl-propionylamino)-6-ethyl-pyrimidin-4-yl]-2,2-dimethyl-propionamide 
• 71523-78-9 Diacetamidopyrimethamine 
• 58-14-0 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine 
• 108-24-7 acetic anhydride 

Downstream Products

• 71523-78-9 Diacetamidopyrimethamine 

Relevant articles and documents

Regioselective Deacylation of 2,4-Diacylaminopyrimidine Derivatives by Lewis Acids and Crystal Structures of Two Products

Deacylation of 2,4-diacylamino derivatives of pyrimethamine and related diaminopyrimidines with tin(II) chloride or zinc chloride, in ethanol or propan-2-ol, affords 2-acyl-4-aminopyrimidines exclusively.Regioselective 4-deacylation was observed by 1H NMR spectroscopy and established by crystallographic analysis of the 2,4-dipropionylpyrimidine 11 and the corresponding 4-amino-2-propionylpyrimidine deacylation product 17.The latter exists in the solid state as an unusual base-pair dimer linked by two pairs of equivalent hydrogen bonds.