741274-90-8

Basic information

• Product Name: C₂₂H₁₅N₃O₆
• Synonyms: C₂₂H₁₅N₃O₆
• CAS NO: 741274-90-8
• Molecular Weight: 417.378
• Mol File: 741274-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₅N₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₅N₃O₆(741274-90-8)
• EPA Substance Registry System: C₂₂H₁₅N₃O₆(741274-90-8)

Safety Data

• Hazardous Substances Data: 741274-90-8(Hazardous Substances Data)

Upstream product

• 27329-70-0 5-formylfurane-2-boronic acid 
• 150-13-0 4-amino-benzoic acid 
• 619-67-0 4-Hydrazinobenzoic acid 
• 7147-77-5 5-(4-nitrophenyl)-2-furaldehyde 
• 60875-16-3 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid 

Relevant articles and documents

Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy

Serine, the source of the one-carbon units essential for de novo purine and deoxythymidine synthesis plays a crucial role in the growth of cancer cells. Phosphoglycerate dehydrogenase (PHGDH) which catalyzes the first, rate-limiting step in de novo serine biosynthesis has become a promising target for the cancer treatment. Here we identified H-G6 as a potential PHGDH inhibitor from the screening of an in-house small molecule library based on the enzymatic assay. We adopted activity-directed combinatorial chemical synthesis strategy to optimize this hit compound. Compound b36 was found to be the noncompetitive and the most promising one with IC50 values of 5.96 ± 0.61 μM against PHGDH. Compound b36 inhibited the proliferation of human breast cancer and ovarian cancer cells, reduced intracellular serine synthesis, damaged DNA synthesis, and induced cell cycle arrest. Collectively, our results suggest that b36 is a novel PHGDH inhibitor, which could be a promising modulator to reprogram the serine synthesis pathway and might be a potential anticancer lead worth further exploration.