74128-84-0

Usage

Uses

Used in Organic Synthesis:
2-Bromo-3-iodoanisole is utilized as a reagent in organic synthesis for a variety of reactions, including cross-coupling reactions and arylation processes. Its distinct structure allows for the formation of new chemical bonds and the creation of diverse organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-Bromo-3-iodoanisole serves as a key intermediate in the synthesis of various drugs. Its unique properties facilitate the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Production:
2-Bromo-3-iodoanisole is also employed in the production of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals that can enhance crop protection and yield.
Used in Fine Chemicals Synthesis:
2-Bromo-3-iodoanisole is used as a building block in the synthesis of fine chemicals, which are high-purity chemicals used in various industries, including fragrances, flavors, and specialty chemicals.
Used in Materials Science:
2-Bromo-3-iodoanisole has potential applications in materials science, where its unique structure and properties can be leveraged to develop new materials with specific characteristics for various applications.
Used as Building Blocks for Complex Organic Molecules:
Due to its reactivity and structural features, 2-Bromo-3-iodoanisole is used as a building block for the synthesis of complex organic molecules, which can be employed in advanced chemical research and the development of novel compounds with specific functions.

Upstream product

• 863870-88-6 2-bromo-3-iodophenol 
• 74-88-4 methyl iodide 
• 863870-83-1 O-2-bromo-3-iodophenyl N,N-diethylcarbamate 
• 863870-73-9 O-3-iodophenyl N,N-diethylcarbamate 
• 626-02-8 3-Iodophenol 
• 67853-37-6 2-bromo-1-methoxy-3-nitrobenzene 
• 168335-61-3 N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide 
• 536-90-3 m-Anisidine 
• 56619-93-3 N-(3-methoxyphenyl)pivalamide 
• 112970-44-2 2-bromo-3-methoxyaniline 

Downstream Products

• 1202057-93-9 2-(2-bromo-3-methoxyphenyl)-1-(3,4-dimethoxyphenyl)ethanone 
• 1421187-15-6 1-bromo-1-methoxy-3-((2-methoxy-6-methylphenyl)ethynyl)benzene 
• 1421187-12-3 1-((2-bromo-3-methoxyphenyl)ethynyl)-2-methoxynaphthalene 
• 1421187-07-6 1-((2-bromo-3-methoxyphenyl)ethynyl)-2-methylnaphthalene 

Relevant academic research and scientific papers

How to Achieve High Regioselectivity in Barrier-less Nucleophilic Addition to p-Benzynes Generated via Bergman Cyclization of Unsymmetrical Cyclic Azaenediyne?

Inducing high regioselectivity in nucleophilic addition to p-benzynes, first reported by Perrin and O'Connor et al. (J. Am. Chem. Soc. 2007, 129, 4795-4799) has been a challenge as the reaction involves a very fast barrier-less addition of nucleophile. On

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

PHOSPHORUS-CONTAINING CATALYSTS

The invention provides compounds of general structure I: (Ar1—Ar2—Ar3-E-P(=D)R2-)nMmXnLn″. In this structure: ?Ar1, Ar2 and Ar3 are aromatic groups wherein: —Ar1 and Ar3 are in a 1,3 relationship on Ar2, —each of Ar1, Ar2 and Ar3 optionally comprises one or more ring substituents of formula YR′r wherein each Y independently is absent or is O, S, B, N or Si and each R′ is independently H, halogen, alkyl, cycloalkyl, aryl or heteroaryl and r is 1, 2 or 3, where r is 1 if Y is absent or is O or S, 2 if Y is B or N and 3 if Y is Si, —Ar1, Ar2 and Ar3 are each independently carbocyclic or heterocyclic and each is independently monocyclic, bicyclic or polycyclic and each ring of each of Ar1, Ar2 and Ar3 independently has 5, 6 or 7 ring atoms; ?E is absent or is selected from the group consisting of O, S, NR″, SiR″2, AsR″2 and CR″2; ?M is a complexing metal; ?X is selected from the group consisting of H, F, Br, CI, I, OTf, dba (dibenzylidene acetone), OC(═O)CF3 and OAc; ?L is selected from the group consisting of PR″2, NR″2, OR″, SR″, SiR″3, AsR″3, alkene, alkyne, aryl and heteroaryl, each of said alkene, alkyne, aryl and heteroaryl being optionally substituted, for example with one or more halogens and/or with one or more R groups as defined herein; ?each R is independently alkyl, cycloalkyl, heterocyclyl, heterocycloalkyl, aryl or -, heteroaryl; ?D is absent or is ═S or —O or —Z-linker-Z—, where each Z independently is O or NH or N-alkyl and linker is an alkyl chain of 2-5 carbon atoms in length; ?each R″ is independently H, alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each other than H being optionally substituted, or R″2 is —Z-linker-Z— as defined above; and ?m is 0 or 1 or 2; wherein if m is 0, n is 1, n′ and n″ are 0 and -- is absent; and if m is 1 or 2, n is 1 or 2 and n′ and n″ are integers such that the coordination sphere of M is filled, and D is absent.

Palladium-catalyzed aryl halide carbonylation-intramolecular O-enolate acylation: Efficient isocoumarin synthesis, including the synthesis of thunberginol A

Exposure of a series of a-(o-haloaryl)-substituted ketones to palladium-catalyzed carbonylation conditions leads to the formation of the corresponding isocoumarins. Balloon pressure of CO is sufficient to achieve high yielding reactions, and both cyclic a

Palladium-catalyzed aryl amination-heck cyclization cascade: A one-flask approach to 3-substituted indoles

(Chemical Equation Presented) Two for the price of one: A Pd/dppf-based catalyst provides access to the title compounds from 1,2-dihalogenated aromatic compounds and allylic amines in a single reaction flask. The initial aryl amination step occurs with excellent selectivity for the aryl iodide to ensure the formation of a single indole regioisomer, which can be functionalized in situ by N-arylation (see scheme). dba = dibenzylideneacetone, dppf = 1,1′-bis(diphenylphospanyl)ferrocene.

(2,7-Disubstituted-1,8-biphenylenedioxy)bis(dimethylaluminum) as Bidentate Organoaluminum Lewis Acids: Elucidation and Synthetic Utility of the Double Electrophilic Activation Phenomenon

A series of (2,7-disubstituted-1,8-biphenylenedioxy)bis(dimethylaluminum) (2) has been readily prepared in situ by treatment of the requisite 2,7-disubstituted-1,8-biphenylenediol (1) with Me3Al (2 equiv) in CH2Cl2 at room temperature; this primarily relies on the successful establishment of a new synthetic procedure of 1 starting from inexpensive m-anisidine. Evaluation of 2 as a bidentate organoaluminum Lewis acid has been performed by the reduction of ketonic substrates using Bu 3SnH as a hydride source in comparison to the conventional monodentate Lewis acid dimethylaluminum 2,6-xylenoxide (11), uncovering the significantly high activation ability of 2 toward carbonyl. Particularly, (2,7-dimethyl-1,8-biphenylenedioxy)-bis(dimethylaluminum) (2a) exerted the highest reactivity, which has also been emphasized in the Mukaiyama aldol reaction. The structure of the bidentate Lewis acid 2 was unambiguously determined by single-crystal X-ray diffraction analysis of 2g possessing a bulky 3,5-di-tert-butylphenyl substituent, revealing the rigid dimeric assembly in the solid state. The double electrophilic activation of carbonyl substrate by 2a has been supported by low-temperature 13C NMR analysis as well as theoretical study using the Gaussian 98 program. Moreover, unique stereoselectivity has been observed in the 2a-promoted Mukaiyama Michael addition, and highly chemoselective functionalization of carbonyl compounds in the presence of their acetal counterparts has been realized using 2a. Finally, the effectiveness of 2a for the activation of ether functionality has been demonstrated in the Claisen rearrangement of allyl vinyl ethers.