74133-22-5Relevant academic research and scientific papers
Intramolecular Reactions of Reissert Compounds
Tyrell, John A.,McEwen, William E.
, p. 2476 - 2479 (2007/10/02)
2--1,2-dihydroisoquinaldonitrile (1) upon treatment with base yielded 5,6,13,14-didehydro-8-oxoberbine (3). 6,7-Dimethoxyisoquinoline gave 2--6,7-dimethoxy-1,2-dihydroisoquinaldonitrile (4) which reacted with base to yield 2,3-dimethoxy-5,6,13,14-didehydro-8-oxoberbine (5). 2-(o-Formylbenzoyl)-1,2-dihydroisoquinaldonitrile (7) reacted with base to form phthalideisoquinoline (10).
A CONVENIENT SYNTHESIS OF 8-OXOPROTOBERBERINE DERIVATIVES
Ruchirawat, Somsak,Lertwanawatana, Werawat,Thepchumrune, Pongtip
, p. 189 - 192 (2007/10/02)
The annulation of isoquinoline derivatives to form the 8-oxoprotoberberine derivatives is described.The key step of the reaction involves intramolecular alkylation of the Reissert compounds.
