74136-42-8

Upstream product

• 99934-01-7 Phenyl-(3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-methanone 
• 73112-02-4 3-phenyl-3H-[1,2,3]triazolo-[4,5-d]pyrimidine 
• 98-80-6 phenylboronic acid 
• 120621-67-2 1-Phenyl-4-benzoyl-5-amino-1H-1,2,3-triazole 
• 21555-09-9 (E)-3-Amino-1-phenyl-3-phenylamino-propenone 
• 17466-00-1 7-chloro-3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 
• 129959-35-9 N'-(5-Benzoyl-3-phenyl-3H-[1,2,3]triazol-4-yl)-N,N-dimethyl-formamidine 

Relevant academic research and scientific papers

Silver-Catalyzed Direct C6–H Arylation of Purines and Purine Nucleosides with Arylboronic Acids

A practical and operationally simple protocol for the assembly of 6-aryl-substituted purines through the direct C6–H arylation of purines and 8-azapurine and purine nucleosides from arylboronic acids was developed. This reaction was performed under ambient conditions with ammonium persulfate as the oxidant in the presence of silver(I). The reaction was found to be regioselective with the arylation occurring predominantly at the C6 position, and a large variety of functional groups, including halides, esters, hydroxy groups, and heterocycles, were tolerated.

RING OPENING OF 4-CHLOROQUINAZOLINE INTO 2-ARYLMETHYLENEAMINOBENZONITRILE BY GRIGNARD REACTION

The treatment of 4-chloroquinazoline (1) with arylmagnesium bromide (3) in tetrahydrofuran (THF) resulted in the formation of 2-arylmethyleneaminobenzonitrile (2).Continued reaction of ring opening of 1 and subsequent hydrolysis of the products (2) afforded the corresponding arenecarbaldehydes (4).

SYNTHESIS OF DERIVATIVES OF 5-AMINO-4-ACYL-1,2,3-TRIAZOLE, 8-AZAPURINE, AND 1,2,3-TRIAZOLOPYRIDIN-7-ONE USING N,N-ACETALS OF ACYLKETENES AND TOSYLAZIDE

By reaction of N,N-acetals of acylketenes with tosylazide there were synthesized 5-amino-4-acyl-1,2,3-triazoles substituted at the endo(N1)-or exocyclic nitrogen atom.Triazoles containing a free NH2 group were used in the synthesis of the corre

Triazolopyrimidines. VIII. Aryl Migration of 7-Aroyl-3H-1,2,3-triazolopyrimidines to 7-Aryl-3H-1,2,3-triazolopyrimidines

When mixtures of 7-chloro-3-phenyl-3H-1,2,3-triazolopyrimidine (4), aromatic aldehydes (5), and a catalytic amount of 1,3-dimethylbenzimidazolium iodide were refluxed in tetrahydrofuran (THF) in the presence of sodium hydride, 7-aroyl-3-phenyl-3H-1