74143-86-5

Upstream product

• 532-27-4 1-chloroacetophenone 
• 536-74-3 phenylacetylene 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 103-80-0 phenylacetyl chloride 
• 53949-11-4 γ-phenyl-α-phenylmethylene-Δ^β,γ-butenolide 

Downstream Products

• 1332525-01-5 (Z)-3-benzyl-2-methyl-5-oxo-5-phenylpent-2-enenitrile 
• 1332525-03-7 (E)-3-benzyl-2-methyl-5-oxo-5-phenylpent-2-enenitrile 
• 1332524-49-8 1-benzoyl-2,6-dibenzyl-3-cyano-4-phenylbenzene 
• 1350307-77-5 1,4-diphenyl-2-(2-phenylvinylidene)butane-1,4-dione 
• 1350307-78-6 1-phenyl-2-(2-phenylvinylidene)-4-p-tolylbutane-1,4-dione 
• 1292816-18-2 3-(4-bromophenyl)-2,5-diphenylfuran 
• 36846-09-0 3-(4-methoxyphenyl)-2,5-diphenylfuran 
• 6307-20-6 2,3,5-triphenylfuran 
• 110851-33-7 2,5-diphenyl-3-(p-tolyl)furan 
• 955-83-9 2,5-diphenylfuran 

Relevant academic research and scientific papers

Copper-Catalyzed One-Pot Synthesis of 1,3-Enynes from 2-Chloro-N-(quinolin-8-yl)acetamides and Terminal Alkynes

A method for the chemo-, regio-, and stereoselective one-pot synthesis of 1,3-enynes is described. The reaction of 2-chloro-N-(quinolin-8-yl)acetamides with terminal alkynes proceeds smoothly in the presence of a copper catalyst at room temperature to produce (E)-1,3-enynes in satisfactory to excellent yields. The mechanism study reveals that the cross-dimerization of internal alkynes generated in situ with terminal alkynes proceeds via allene intermediates. The directing group 8-aminoquinoline plays a key role in the current selective synthesis of (E)-1,3-enynes.

Tandem reactions of 1,2-allenic ketones leading to substituted benzenes and α,β-unsaturated nitriles

One-pot double Michael addition/intramolecular aldol reaction/ decarboxylation of 1,2-allenic ketones with cyanoacetate offers an efficient and convenient approach to highly functionalized benzenes. With 2-substituted cyanoacetates, the reaction proceeds via a different tandem process to afford α,β-unsaturated nitriles effectively.