74145-30-5

Upstream product

• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 119-36-8 methyl salicylate 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 31255-10-4 1,2-bis-(2-bromo-ethoxy)-ethane 
• 201596-36-3 methyl-2-[2-(2-2-[2-(methoxycarbonyl) phenoxy] ethoxyethoxy) ethoxy] benzoate 
• 74145-32-7 2,2'-(3,6-Dioxaoctamethylendioxy)dibenzoesaeure-diethylester 

Downstream Products

• 201596-37-4 1,10-bis(2'-benzoyl chloride)-1,4,7,10-tetraoxadecane 

Relevant academic research and scientific papers

Ring-closing metathesis reaction-based synthesis of new classes of polyether macrocyclic systems

Ring closing metathesis (RCM) reactions of suitable substrates having terminal olefins, which are assembled from various linkers and hydroxy benzaldehydes and syntheses of a wide range of 16-30 membered, new crown ether-type polyether, aza-polyether, bis aza-polyether macrocycles and dilactone moiety embedded polyether macrocycles (macrolides) are reported. After the ring-closure reaction, installation of different functional groups and functional group modification on the periphery of the synthesized polyether/crown ether macrocycles obtained in the RCM reactions are accomplished using the epoxidation, oxidation and catalytic hydrogenation-based synthetic transformations. Along this line, the syntheses of a variety of polyether macrocycles possessing epoxide or α-hydroxy ketone or 1,2-diol functionalities at the periphery have been shown. Furthermore, the synthesized α-hydroxy ketone functionality installed polyether macrocycles were subjected to the allylation and Reformatsky type reactions to obtain homoallyl alcohol moiety-based and lactone ring-appended polyether macrocycles.

Efficient synthesis of macrocyclic dilactam crown ethers by fast addition method

A simple and convenient method for preparing macrocyclic dilactam crown ethers containing N2O5, N3O3, N 3O4, N3O5 and N2O 10 donor atoms with 18-32 membered

Synthesis and infrared and fluorescence spectral properties of luminescent terbium and europium complexes with open-chain carboxylate crown ethers.

Two open-chain carboxylate crown ether ligands and their terbium(III) and europium(III) complexes were synthesized and characterized. The terbium and europium ions were found to coordinate to the carboxylate oxygens. The fluorescence properties of europium complexes in the solid state and terbium complexes in the solid state and in the organic solvent were studied in detail, respectively. Under the excitation of ultraviolet light, strong green fluorescence of solid terbium complexes and red fluorescence of solid europium complexes were observed. These observations show that the two ligands favor energy transfer to the emitting energy level of Tb(3+). Some factors that influencing the fluorescent intensity were also discussed.

New fluorimetric alkali and alkaline earth metal cation sensors based on noncyclic crown ethers by means of intramolecular excimer formation of pyrene

New fluorescent reagents, 2,2′-[oxybis(3-oxapentamethyleneoxy)]-bis[N-(1-pyrenylmethyl)benzamide)] (4) and its analogues (2, 3, and 5) which have two pyrenes at the both terminals of polyoxyethylene compounds, were synthesized, and their complexation behavior with alkaline earth cations was investigated by fluorescence spectrometry, fluorescence lifetimes, and 1H NMR spectrometry. These reagents (3-5) showed strong intramolecular excimer emissions around at 480 nm in the fluorescence spectra. On the complexation with alkaline earth metal cations, the increase of monomer emission around at 400 nm accompanied by the disappearance of intramolecular excimer emission of free reagents was observed. These reagents formed a 1:1 complex, and the order of complex formation constants was Ca2+ ? Sr2+ > Ba2+ > Mg2+ > Li+ for all reagents. 1H NMR spectra of these complexes with alkaline earth cations suggested the helical structures of the complexes. Fluorescence spectral changes at the formation of complexes depended on the chain length of the oxyethylene moiety and metal cations. In all cases, the formation of helical structures at the complexation was supported by the 1H NMR spectra.

Crown Ethers as New Catalysts in the Highly Regioselective Halogenative Cleavage of Epoxides with Elemental Halogen

The regioselective ring opening halogenation of some epoxides using elemental iodine and bromine in the presence of a series of new synthetic macrocycle diamides and also dibenzo-18-crown -6, 18-crown-6, and aza-18-crown-6 has been studied. The epoxides were subject to cleavage by elemental halogen (I2 and Br2) in the presence of these catalysts under mild reaction conditions in various aprotic solvents. In this study, reagents and conditions have been discovered with which the individual halohydrins can be synthesized in high yield and with more than 95% regioselectivity. The results can be discussed in terms of a four-step mechanism: (1) formation of a charge-transfer complex between catalyst and halogen, (2) release of halogen nucleophile from the complex, (3) reaction of the active nucleophile at the less sterically-hindered site in the epoxide, and (4) regeneration of catalyst. The major advantages of this method are high regioselectivity, simple regeneration of catalyst and its reuse through several cycles without a decrease in activity, and ease of workup of the reaction.

Selective Liquid Membrane Transport of Lead(II) by an Acyclic Polyether Dicarboxylic Acid Ionophore

The effects of the chain structure and substitutents in six acyclic polyether dicarboxylic acids and one acyclic polyether carboxylic acid upon the efficiency and selectivity of pH-driven Pb2+ transport in a bulk chloroform membrane system have

Calcium ionophores as cardiac stimulants. I. Diacids derived from dibenzo crown ethers

A series of calcium chelating agents has been prepared based on carboxylic derivatives of open chain 18-Crown-6 analogues. Most of these are efficient calcium binding agents, many form lipophilic calcium complexes, and some of these are capable of releasing Ca2+ from liposomes by ionophore action. The best of these is 1,2-bis-[2-(1-carboxydecyloxy)phenoxy]ethane. This compound is cardiotonic in vitro but in the dog vasoconstriction it is the predominant biological effect.

Ligand Structure and Complexation, LI. - Multidentate Neutral Ligands with Variable Cavities and Pseudo Cavities

New cyclic and non-cyclic neutral ligand systems have been synthesized.They contain repeating oligoethylene glycol ethers and carboxamide functions, which allow attractive interactions between single chain segments and with terminal groups.Crystalline com