74156-60-8Relevant academic research and scientific papers
Large-scale solvent-free chlorination of hydroxy-pyrimidines,-pyridines,- pyrazines and-amides using equimolar POCl3
Wang, Han,Wen, Kun,Wang, Le,Xiang, Ye,Xu, Xiaocheng,Shen, Yongjia,Sun, Zhihua
experimental part, p. 4533 - 4544 (2012/06/30)
Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines,-quinoxalines, or even-amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.
EMEHETERONE: SYNTHESIS AND STRUCTURAL REVISION
Ohta, Akihiro,Kojima, Akihiko,Aoyagi, Yutaka
, p. 1655 - 1662 (2007/10/02)
Emeheterone, a fungal metabolite, was synthesized from DL-phenylalanine.Based on the results of this synthesis, the structure of emeheterone was redetermined as 3,6-dibenzyl-2-hydroxy-5-methoxypyrazine 4-oxide.
