74157-47-4

Basic information

• Product Name: 1-(3-BROMOPHENYL)PROPAN-1-OL
• Synonyms: 1-(3-BROMOPHENYL)PROPAN-1-OL
• CAS NO: 74157-47-4
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.09
• Mol File: 74157-47-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3-BROMOPHENYL)PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMOPHENYL)PROPAN-1-OL(74157-47-4)
• EPA Substance Registry System: 1-(3-BROMOPHENYL)PROPAN-1-OL(74157-47-4)

Safety Data

• Hazardous Substances Data: 74157-47-4(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Molecular weight

213.08 g/mol

Structure

Contains a benzene ring with a bromine atom attached at the 3-position and a propan-1-ol group attached at the 1-position

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Used in organic synthesis and research applications

Reactivity

Versatile reactivity and potential as a building block for the construction of more complex molecules

Safety precautions

a. May be harmful if ingested
b. May be harmful if inhaled
c. May be harmful if in contact with skin
d. Handle with caution

Upstream product

• 108-36-1 1,3-dibromobenzene 
• 123-38-6 propionaldehyde 
• 19829-31-3 1-(3-bromophenyl)-1-propanone 
• 74-96-4 ethyl bromide 
• 3132-99-8 m-bromobenzoic aldehyde 
• 925-90-6 ethylmagnesium bromide 
• 186000-44-2 (3-bromophenyl)zinc (II) iodide 

Downstream Products

• 1019940-69-2 C₁₁H₁₃BrO₂ 
• 19829-32-4 1-bromo-3-propylbenzene 
• 166337-53-7 1-bromo-3-(1-bromopropyl)benzene 
• 247233-64-3 {2-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-1-[1-(3-cyclohexylmethyl-phenyl)-propylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 247233-57-4 2-[1-(3-cyclohexylmethyl-phenyl)-propyl]-isoindole-1,3-dione 
• 247233-60-9 1-(3-cyclohexylmethyl-phenyl)-propylamine 
• 224622-38-2 (S)-1-(3'-bromophenyl)-1-propanol 

Relevant articles and documents

NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF

A class of compounds that bind to fatty acid binding protein (FABP4) and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4.

Highly enantioselective dynamic kinetic resolution of alkyl aryl carbinols carrying a trimethylsilyl group with a highly active lipoprotein lipase preparation

Abstract The kinetic and dynamic kinetic resolution of alkyl aryl carbinols carrying a trimethylsilyl group with a highly active lipase preparation containing lipoprotein lipase, dextrin, and ionic surfactant 1 has been explored. It was found that all the trimethylsilyl-containing substrates were accepted by lipoprotein lipase-dextrin 1 (LPL-D1) with perfect enantioselectivity (E = >200). As a result, the dynamic kinetic resolution of these substrates with LPL-D1 in the presence of a Ru-based racemization catalyst provided single enantiomeric products (>99% ee) with good yields. Furthermore, the dynamic kinetic resolution products were readily desilylated or halodesilylated to yield enantiopure alkyl aryl carbinols. Thus a useful protocol for the highly enantioselective synthesis of alkyl aryl carbinols, particularly those carrying a long alkyl chain (C6-C10) has been established.

Kinetic resolution of aryl alkenylcarbinols catalyzed by Fc-PIP

An effective kinetic resolution of a variety of aryl alkenylcarbinols catalyzed by nonenzymatic acyl transfer catalyst Fc-PIP was developed, affording corresponding unreacted alcohols in good to excellent ee value up to 99% and with selectivity factors up to 24.