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1-(3-BROMOPHENYL)PROPAN-1-OL is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

74157-47-4

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74157-47-4 Usage

Physical state

Colorless liquid

Molecular weight

213.08 g/mol

Structure

Contains a benzene ring with a bromine atom attached at the 3-position and a propan-1-ol group attached at the 1-position

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Used in organic synthesis and research applications

Reactivity

Versatile reactivity and potential as a building block for the construction of more complex molecules

Safety precautions

a. May be harmful if ingested
b. May be harmful if inhaled
c. May be harmful if in contact with skin
d. Handle with caution

Check Digit Verification of cas no

The CAS Registry Mumber 74157-47-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,1,5 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 74157-47:
(7*7)+(6*4)+(5*1)+(4*5)+(3*7)+(2*4)+(1*7)=134
134 % 10 = 4
So 74157-47-4 is a valid CAS Registry Number.

74157-47-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (+/-)-1-(3-bromophenyl)propanol

1.2 Other means of identification

Product number -
Other names 1-(3-bromophenyl)propan-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74157-47-4 SDS

74157-47-4Relevant articles and documents

NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF

-

Page/Page column 245-246, (2021/07/31)

A class of compounds that bind to fatty acid binding protein (FABP4) and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4.

AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17

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Page/Page column 83, (2020/07/14)

The present invention relates to a compound according to formula I (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

Highly enantioselective dynamic kinetic resolution of alkyl aryl carbinols carrying a trimethylsilyl group with a highly active lipoprotein lipase preparation

Cho, Jeonghun,Lee, Jusuk,Park, Jaiwook,Kim, Mahn-Joo

, p. 840 - 845 (2015/08/18)

Abstract The kinetic and dynamic kinetic resolution of alkyl aryl carbinols carrying a trimethylsilyl group with a highly active lipase preparation containing lipoprotein lipase, dextrin, and ionic surfactant 1 has been explored. It was found that all the trimethylsilyl-containing substrates were accepted by lipoprotein lipase-dextrin 1 (LPL-D1) with perfect enantioselectivity (E = >200). As a result, the dynamic kinetic resolution of these substrates with LPL-D1 in the presence of a Ru-based racemization catalyst provided single enantiomeric products (>99% ee) with good yields. Furthermore, the dynamic kinetic resolution products were readily desilylated or halodesilylated to yield enantiopure alkyl aryl carbinols. Thus a useful protocol for the highly enantioselective synthesis of alkyl aryl carbinols, particularly those carrying a long alkyl chain (C6-C10) has been established.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

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Page/Page column 145, (2014/05/07)

Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

Kinetic resolution of aryl alkenylcarbinols catalyzed by Fc-PIP

Hu, Bin,Meng, Meng,Jiang, Shanshan,Deng, Weiping

scheme or table, p. 1289 - 1294 (2012/08/28)

An effective kinetic resolution of a variety of aryl alkenylcarbinols catalyzed by nonenzymatic acyl transfer catalyst Fc-PIP was developed, affording corresponding unreacted alcohols in good to excellent ee value up to 99% and with selectivity factors up to 24.

SUBSTITUTED PARA-BIPHENYLOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

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Page/Page column 74, (2011/04/19)

The present invention relates to a series of substituted para-biphenyloxymethyl dihydro oxazolopyrimidinones of formula (I) as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of

N, N′-dioxide-Cu(OTf)2 complex catalyzed highly enantioselective amination reaction of N-acetyl enamide

Chang, Lu,Kuang, Yulong,Qin, Bo,Zhou, Xin,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming

supporting information; experimental part, p. 2214 - 2217 (2010/08/06)

The N,N′-dioxide-Cu(OTf)2 complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.

Screening of liver acetone powders in the resolution of 1-phenylethanols and 1-phenylpropanols derivatives

Solis, Aida,Garcia, Susana,Perez, Herminia I.,Manjarrez, Norberto,Luna, Hector

, p. 549 - 553 (2008/09/20)

Hydrolases from the liver acetone powders (LAPs) of bovine, cat, chicken, turkey, lamb, pig, rabbit, and rat were assessed for the enantioselective hydrolysis of acetates of 1-(4-chlorophenyl)ethanol, 1-(3-bromophenyl)ethanol, 1-(4-chlorophenyl)propanol, 1-(4-bromophenyl)propanol, and 1-(3-bromophenyl)propanol. The enantioselectivity of the hydrolytic reaction was dependent upon the liver hydrolase, substrate, pH of the reaction media, and the cosolvent. The most ester selective LAP was from chicken, and the resulting alcohols had the highest ee (80% to >99%). All of the LAPs tested catalyzed the hydrolysis of 1-(4-chlorophenyl)ethanol, except for lamb LAP.

Synthesis and antifungal activity of novel 14-membered benzomacrolides, as galbonolide analogues

Sakoh, Hiroki,Sakuraba, Shunji,Sugimoto, Yuichi,Imamura, Hideaki,Jona, Hideki,Yamada, Koji,Bamba-Nagano, Rie,Hashizume, Terutaka,Morishima, Hajime

, p. 163 - 165 (2007/10/03)

Asymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring instead of a conjugated diene structure, was achieved starting from chiral 1-aryl-1-propanol obtained by enzyme-catalyzed kinetic

Selective halogen - Magnesium exchange reaction via organomagnesium ate complex

Inoue,Kitagawa,Shinokubo,Oshima

, p. 4333 - 4339 (2007/10/03)

Halogen-magnesium exchange of various aryl halides is achieved with a magnesium ate complex at low temperatures. Tributylmagnesate (nBu3MgLi) induces facile iodine-magnesium exchange at -78 °C. Dibutylisopropylmagnesate (iPrnBu2MgLi) is more reactive than nBu3MgLi, and this reagent accomplishes selective bromine-magnesium exchange at -78 °C. This procedure is utilized for the preparation of various polyfunctionalized arylmagnesium species. The exchange of alkenyl halides using this method proceeds with retention of configuration of the double bond.

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