741606-16-6

Upstream product

• 1670-81-1 1H-Indole-5-carboxylic acid 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 

Downstream Products

• 921192-87-2 5-tert-butyl 3-methyl 1-[3-(4-decyloxyphenoxy)-2-oxopropyl]indole-3,5-dicarboxylate 
• 921192-85-0 5-tert-butyl 3-methyl 1-[3-(4-decyloxyphenoxy)-2-hydroxypropyl]indole-3,5-dicarboxylate 
• 888320-29-4 1-[3-(4-decyloxy-phenoxy)-2-oxo-propyl]-1H-indole-3,5-dicarboxylic acid 3-methyl ester 
• 741606-41-7 1-[3-(4-octylphenoxy)-2-oxo-propyl]indole-3,5-dicarboxylic acid 5-tert-butyl ester 3-methyl ester 
• 741606-40-6 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylic acid 5-tert-butyl ester 3-methyl ester 
• 741606-34-8 3-formyl-1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-5-carboxylic acid tert-butyl ester 
• 741606-35-9 3-formyl-1-[3-(4-octylphenoxy)-2-oxo-propyl]indole-5-carboxylic acid tert-butyl ester 
• 741606-43-9 1-[3-(4-decyloxy-phenoxy)-2-oxo-propyl]-1H-indole-5-carboxylic acid tert-butyl ester 
• 741606-31-5 3-chloro-1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-5-carboxylic acid tert-butyl ester 
• 741606-32-6 3-chloro-1-[3-(4-octylphenoxy)-2-oxo-propyl]indole-5-carboxylic acid tert-butyl ester 
• 741606-18-8 tert-butyl 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylate 
• 741606-42-8 1-[3-(4-decyloxy-phenoxy)-2-hydroxy-propyl]-1H-indole-5-carboxylic acid tert-butyl ester 
• 741606-17-7 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-5-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Convenient synthesis of tert-butyl esters of indole-5-carboxylic acid and related heterocyclic carboxylic acids

The tert-butyl esters of indole-5-carboxylic acid and related compounds such as benzofuran- and benzothiophene-5-carboxylic acid were readily accessed by reacting the appropriate carboxylic acids with tert-butyl trichloroacetimidate. To obtain the tert-butyl esters of the 5-carboxylic acids of 1H-benzotriazole and 1H-benzimidazole, position 1 of these heterocycles had to be protected by acetylation prior to reaction with tert-butyl trichloroacetimidate. Cleavage of the acetyl residue of the obtained intermediates by dilute aqueous NaOH in ethanol led to the desired tert-butyl 1H-benzotriazole-and 1H-benzimidazole-5-carboxylates. Copyright Taylor & Francis Group, LLC.

Convenient synthesis of pyrrole- and indolecarboxylic acid tert-butylesters

The tert-butylesters of pyrrole- and indolecarboxylic acids are readily accessed by reacting the appropriate carboxylic acids with N,N-dimethylformamide di-tert-butyl acetal.

NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVES AS INHIBITORS OF PHOSPHOLIPASE A2

The invention relates to novel heteroaryl-substituted acetone derivatives, which inhibit the enzyme phospholipase A2, to pharmaceutical agents that contain said compounds and to a method for producing said compounds.