741683-19-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2-fluoroisonicotinic acid is used as an intermediate or base material for the manufacturing of more complex chemical substances, particularly in the development of pharmaceutical drugs and biologically active compounds. Its unique properties contribute to the synthesis of new drug candidates and the enhancement of existing medications.
Used in Research and Development:
3-Chloro-2-fluoroisonicotinic acid is employed as a key component in various chemical reactions, facilitating the discovery and synthesis of novel compounds with potential applications in medicine, agriculture, and other fields. Its reactivity and stability make it a valuable asset in the advancement of scientific knowledge and the creation of innovative products.

InChI:InChI=1/C6H3ClFNO2/c7-4-3(6(10)11)1-2-9-5(4)8/h1-2H,(H,10,11)

Upstream product

• 1480-64-4 3-chloro-2-fluoropyridine 
• 124-38-9 carbon dioxide 
• 2402-77-9 2,3-dichloro-pyridine 

Downstream Products

• 741683-20-5 1'-benzylspiro[4-chloro-5-fluoro-6-azaisobenzofuran-1(3H)-4-piperidin]-3-one 

Relevant academic research and scientific papers

CYCLOALKANOPYRIDINE DERIVATIVE

Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.

MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISTS CONTAINING PIPERIDINE DERIVATIVES AS THE ACTIVE INGREDIENT

The invention provides melanin-concentrating hormone receptor antagonists containing as the active ingredient piperidine derivatives represented by the general formula [I]: ???[wherein R1 is hydrogen, hydroxyl, lower alkyl, or the like; R2, R3a, R3b, R4a, R4b, R5a, R5b and R6 each stands for hydrogen, halogen, or the like; W1 and W2 each independently stands for -O-, -CH2-, or the like; Y1, Y2, Y3 and Y4 stand for -CH-, -CF-, -N-, or the like; Z stands for lower alkyl, an aliphatic heterocyclic group, or the like; Ar is a mono- or bi-cyclic aliphatic heterocycle or an aromatic heterocycle; and n is an integer of 1 to 8]. The compounds act as antagonist against melanin-concentrating hormone receptor and are useful as drugs for central diseases, circulatory diseases, or metabolic diseases.