741693-83-4 Usage
Chemical Properties
Tan Solid
Uses
4-Hydroxy Duloxetine Glucuronide is a derivative of 4-Hydroxy Duloxetine (H941800), a major metabolite of Duloxetine (D721000), which acts as an antidepressant and a dual serotonin and norepinephrine reuptake inhibitor (SNRI). Exhibits linear pharmacokinetics in mice and is not associated in any drastic changes of blood pressure or heart rate.
Check Digit Verification of cas no
The CAS Registry Mumber 741693-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,1,6,9 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 741693-83:
(8*7)+(7*4)+(6*1)+(5*6)+(4*9)+(3*3)+(2*8)+(1*3)=184
184 % 10 = 4
So 741693-83-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H27NO8S/c1-25-11-10-17(18-7-4-12-34-18)31-15-8-9-16(14-6-3-2-5-13(14)15)32-24-21(28)19(26)20(27)22(33-24)23(29)30/h2-9,12,17,19-22,24-28H,10-11H2,1H3,(H,29,30)/t17-,19?,20?,21?,22?,24?/m0/s1
741693-83-4Relevant articles and documents
Synthesis and biological activity of some known and putative duloxetine metabolites
Kuo,Gillespie,Kulanthaivel,Lantz,Ma,Nelson,Threlkeld,Wheeler,Yi,Zmijewski
, p. 3481 - 3486 (2007/10/03)
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.
