7417-67-6

Basic information

• Product Name: N-methyl-N-nitrosoacetamide
• Synonyms: N-methyl-N-nitrosoacetamide;N-Nitroso-N-methylacetamide
• CAS NO: 7417-67-6
• Molecular Formula: C3H6 N2 O2
• Molecular Weight: 102.11
• Mol File: 7417-67-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 191.38°C (rough estimate)
• Flash Point: 21.1°C
• Appearance: /
• Density: 1.3516 (rough estimate)
• Vapor Pressure: 22.8mmHg at 25°C
• Refractive Index: 1.4715 (estimate)
• Water Solubility: 17.36g/L(24 oC)
• CAS DataBase Reference: N-methyl-N-nitrosoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-nitrosoacetamide(7417-67-6)
• EPA Substance Registry System: N-methyl-N-nitrosoacetamide(7417-67-6)

Safety Data

• Hazardous Substances Data: 7417-67-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C3H6N2O2/c1-3(6)5(2)4-7/h1-2H3

Upstream product

• 79-16-3 N-methyl-acetamide 
• 56-23-5 tetrachloromethane 
• 75-09-2 dichloromethane 
• 10544-72-6 dinitrogen tetraoxide 

Downstream Products

• 27129-78-8 N-Acetyl-N-methylhydrazon von 3,5-Dimethylbenzaldehyd 

Relevant articles and documents

Kinetic Studies on the Formation of N-Nitroso Compounds, X. The Nitrosation of N-Methylacetamide and Its Differences with Respect to the Nitrosation of Amines

The kinetics of the nitrosation of N-methylacetamide have been studied using specrophotometry.Significant differences with respect to the mechanism of nitrosation of amines were observed: the absence of catalysis by halides, the existence of general basic catalysis by acetate and its chlorated derivatives obeying Broensted's law (with β = 0.49), and the primary isotopic effect (with a ratio of 7.9 between the rate constants for the elementary process in H2O and D2O).All this indicates that the slow step of the mechanism must be the transfer of a proton from the protonated nitrosamide to the reaction medium. - Keywords: Kinetics of nitrosation; N-Nitrosation of N-methylacetamide; Proton transfer

Selective N-nitrosation of amines, N-alkylamides and N-alkylureas by N2O4 supported on cross-linked polyvinylpyrrolidone (PVP-N2O4)

N2O4 was supported on the cross-linked polyvinylpyrrolidone (PVP) to afford a solid, stable and recyclable nitrosating agent. This reagent shows excellent selectivity for N-nitrosation of dialkyl amines in the presence of diaryl-, arylalkyl-, trialkylamines and also for secondary amides in dichloromethane at room temperature under mild and heterogeneous conditions. Also N-nitroso-N-alkyl amides can be selectively prepared in the presence of primary amides and N-phenylamides under similar reaction conditions. Selective N-nitrosation or dealkylation and N-nitrosation of tertiary amines can also be performed by this reagent.

The synthesis of potential anticancer agents. XXXVII. N-nitrosoureas. 3. 1,5-bis(2-chloroethyl)-1-nitrosobiuret and related derivatives of biurets, biureas, and carboxamides.

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