74173-59-4

Upstream product

• 13327-27-0 6-Methylpyridazin-3(2H)-on 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 87780-07-2 2-Bromo-1-(4-bromo-phenyl)-2-[6-methyl-2-p-tolyl-2H-pyridazin-(3Z)-ylidene]-ethanone 
• 87780-05-0 1-(4-Bromo-phenyl)-2-[6-methyl-2-p-tolyl-2H-pyridazin-(3E)-ylidene]-ethanone 
• 87780-13-0 6-Methyl-2-p-tolyl-2H-pyridazine-3-thione 

Relevant academic research and scientific papers

N-aryl heterocycles via coupling reactions with arylboronic acids

Compounds having a partial 2-pyridone structure or 3-pyridazinones can be selectively N-arylated with phenylboronic acids according to the procedure described by Chan and Lam. This procedure leads to N5-arylated imidazo[4,5- c]pyridin-4-ones, precursors of potent factor Xa inhibitors. In addition, the synthesis of N-aryl substituted pyrrole- and indole-2-carboxylic acid esters is described. In the indole series this procedure offers a flexible entry in the synthesis of different 1,3-diaryl-2-carboxyindoles.