74185-31-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Ethynyl Benzoic Acid ethyl ester is used as a reagent and intermediate for the synthesis of various compounds, playing a crucial role in the development of new pharmaceuticals.
Used in Organic Electronics:
2-Ethynyl Benzoic Acid ethyl ester is used as a building block in the synthesis of functional materials, contributing to the advancement of organic electronic devices.
Used in Research and Development:
2-Ethynyl Benzoic Acid ethyl ester is utilized in research for its potential applications in various fields, including the development of new materials and compounds with unique properties.

Upstream product

• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 110166-76-2 ethyl 2-((trimethylsilyl)ethynyl)benzoate 
• 1829-28-3 ethyl 2-iodobenzoate 

Downstream Products

• 74185-33-4 2-((Z)-2-Methylselanyl-vinyl)-benzoic acid ethyl ester 
• 74185-36-7 2-((Z)-2-Methyltellanyl-vinyl)-benzoic acid ethyl ester 
• 1208108-45-5 C₂₁H₂₃ClN₄O₅ 
• 1215119-95-1 (Z)-1-(2-ethoxycarbonylphenyl)-4-chlorobut-3-en-1-yne 
• 74185-35-6 2-((Z)-2-Methyltellanyl-vinyl)-benzoic acid 
• 74185-32-3 2-((Z)-2-Methylselanyl-vinyl)-benzoic acid 

Relevant academic research and scientific papers

Synthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block

A novel fluoroalkyl iodide was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. We demonstrated its applicability in a metal-free photocatalytic ATRA reaction to synthesize valuable fluoroalkylated vinyl iodides and proved the straightforward transformability of the products in cross-coupling chemistry to obtain conjugated systems.

Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

Despite the long history and interesting properties of propellanes, these compounds still have tremendous potential to be exploited in synthetic organic chemistry. Herein we disclose an experimentally simple procedure to achieve cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with ethynes.

Cobalt(II)-based Metalloradical Activation of 2-(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation

A new catalytic method for the denitrogenative transannulation/cyclopropanation of in-situ-generated 2-(diazomethyl)pyridines is described using a cobalt-catalyzed radical-activation mechanism. The method takes advantage of the inherent properties of a CoIII-carbene radical intermediate and is the first report of denitrogenative transannulation/cyclopropanation by a radical-activation mechanism, which is supported by various control experiments. The synthetic benefits of the metalloradical approach are showcased with a short total synthesis of (±)-monomorine.