74185-83-4

Usage

Uses

Used in Chemical Production:
(1,1-Difluoropropyl)benzene is utilized as a solvent and in the production of other chemicals, contributing to the synthesis of a wide range of compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (1,1-Difluoropropyl)benzene is used as an intermediate for the synthesis of various pharmaceuticals, playing a crucial role in the development of new medications.
Used in Agrochemical Production:
(1,1-Difluoropropyl)benzene is also employed as an intermediate in the synthesis of agrochemicals, which are essential for the agricultural sector to ensure crop protection and yield enhancement.
Used in Specialty Chemicals Synthesis:
(1,1-Difluoropropyl)benzene is used in the synthesis of specialty chemicals, which are important for various industrial applications, including the production of high-performance materials and advanced chemical formulations.

Upstream product

• 32770-66-4 1-(1-phenylpropylidene)hydrazine 
• 3375-37-9 propiophenone-(2,4-dinitro-phenylhydrazone) 
• 6008-82-8 2-ethyl-2-phenyl-1,3-dithiolane 
• 74-85-1 ethene 
• 98-08-8 α,α,α-trifluorotoluene 

Relevant academic research and scientific papers

Selective C-F Functionalization of Unactivated Trifluoromethylarenes

Fluorinated organic molecules are pervasive within the pharmaceutical and agrochemical industries due to the range of structural and physicochemical properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl-CF2 functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a general method for the synthesis of aryl-CF2R and aryl-CF2H compounds through activation of the corresponding trifluoromethyl arene precursors. This strategy is enabled by an endergonic electron transfer event that provides access to arene radical anions that lie outside of the catalyst reduction potential. Fragmentation of these reactive intermediates delivers difluorobenzylic radicals that can be intercepted by abundant alkene feedstocks or a hydrogen atom to provide a diverse array of difluoalkylaromatics.

gem-Difluorination of 1,3-dithiolanes with the hexafluoropropene-diethylamine reagent and N-iodosuccinimide or 1,3-dibromo-5,5-dimethylhydantoin

gem-Difluoro compounds are readily prepared from 1,3-dithiolanes in good yield on treatment with hexafluoropropene-diethylamine/1,3-dibromo-5,5-dimethylhydantoin or /N-iodosuccinimide/water. - Keywords: gem-Difluorination; 1,3-Dithiolanes; NMR spectroscop

Conversion of the Carbonyl Group to CF2 Using IF

A novel method for the transformation of CO -> CF2 is described.The easily made hydrazone derivatives of the carbonyl moiety are reacted under mild conditions with IF prepared directly from the corresponding elements.Various hydrazones have been examined and compared with each other.Unsubstituted ones are usually the most suitable although they are not always easy to purify and store.N-Methyl- and N,N-dimethylhydrazones also give quite satisfactory results.The more easily made dinitrophenyl hydrazones (DNPs), semicarbazones, and tosylhydrazones also react, but the yields of the desired CF2 compounds are usually lower.Oximes could also be successfully reacted.The two main byproducts of the reaction are the parent carbonyl compounds, which can be recycled, and the α-iododifluoro derivatives.The latter upon treatment with LiAlH4 or Bu3SnH were reduced to the desired product, thus increasing the overall yields.