74185-87-8Relevant academic research and scientific papers
Solid-phase synthesis of monocyclic β-lactam derivatives
Schunk,Enders
, p. 8034 - 8042 (2007/10/03)
Liquid-phase studies concerning the solid-phase synthesis of monocyclic β-lactams via the esterenolate imine condensation route have been conducted utilizing triazene esters 1 and 2 as model compounds. Esters were attached to benzylamine resin 6 by a triazene linker employing the respective diazonium salts. Immobilized ester-enolates 8 and 10 were reacted with various imines and imine precursors to give polymer-bound β-lactams 14 and 17 in different substitution patterns. Traceless cleavage from the triazene linker yields the desired β-lactams 16 and 19.
Solid-phase synthesis of beta-lactams via the ester enolate-imine condensation route.
Schunk,Enders
, p. 907 - 910 (2007/10/03)
The ester enolate-imine condensation route to beta-lactams via an immobilized ester enolate has been achieved for the first time. The key reaction in the synthesis is the cyclization of the resin bound ester dianion and an imine. Traceless cleavage from the T1-triazene linker system yields the desired beta-lactams.
Unambiguous Synthesis of 3-Benzoylamino-3-methyl-1,4-diphenyl-2-azetidinone
Kumar, Pradeep,Mukerjee, Arya K.
, p. 420 - 421 (2007/10/02)
3-Methyl-1,4-diphenyl-3-phthalimido-2-azetidinone (5b), obtained by the reaction of phthaloylalaninyl chloride (1b) with benzylideneaniline in the presence of triethylamine, has been converted into the title compound (12) via its amino analogue (11).
