7420-49-7 Usage
Uses
Used in Medicinal Chemistry:
(1E)-phenylethanal thiosemicarbazone is used as a pharmaceutical candidate for its antimicrobial and antitumor properties. It has shown potential in treating various types of cancer and infections, making it a valuable asset in drug development.
Used in Coordination Chemistry:
(1E)-phenylethanal thiosemicarbazone is used as a ligand for forming stable complexes with metal ions. This application is crucial in understanding the coordination properties of metal ions and their potential uses in various chemical reactions and processes.
Used in Analytical Chemistry:
(1E)-phenylethanal thiosemicarbazone is used as a colorimetric and fluorescent sensor for detecting and analyzing metal ions. Its sensitivity and selectivity make it a valuable tool in analytical chemistry for environmental monitoring, industrial processes, and scientific research.
Used in Drug Development:
(1E)-phenylethanal thiosemicarbazone is used as a lead compound in the development of new drugs targeting cancer and infectious diseases. Its unique properties and potential to form complexes with metal ions make it a promising candidate for creating effective therapeutic agents.
Used in Environmental Monitoring:
(1E)-phenylethanal thiosemicarbazone is used as a tool for detecting and analyzing metal ion contaminants in environmental samples. Its application in colorimetric and fluorescent sensing allows for the efficient and accurate monitoring of metal ion levels, contributing to environmental protection and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 7420-49-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,2 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7420-49:
(6*7)+(5*4)+(4*2)+(3*0)+(2*4)+(1*9)=87
87 % 10 = 7
So 7420-49-7 is a valid CAS Registry Number.
7420-49-7Relevant academic research and scientific papers
PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles
Han, Yingzhi,Sun, Yadong,Abdukader, Ablimit,Liu, Bifu,Wang, Duozhi
, p. 3486 - 3491 (2018/09/27)
A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.
Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase
Yi, Wei,Dubois, Carole,Yahiaoui, Samir,Haudecoeur, Romain,Belle, Catherine,Song, Huacan,Hardre, Renaud,Reglier, Marius,Boumendjel, Ahcne
experimental part, p. 4330 - 4335 (2011/11/06)
Melanin play a major role in human skin protection and their biosynthesis is vital. Due to their color, they contribute to the skin pigmentation. Tyrosinase is a key enzyme involved in the first stage of melanin biosynthesis, it catalyzes the transformation of tyrosine into l-dopaquinone. The aim of the present study was to study molecules able to inhibit tyrosinase to be used in treating depigmentation-related disorders. In this study, we targeted arylthiosemicarbazone analogs with the aim to contribute to the identification of the optimal aryl ring to be linked to the thiosemicarbazone moiety. The biological activity was evaluated on commercial mushroom tyrosinase which was purified prior use. The results demonstrated that several of our compounds (1a-h, 1j, 1r and 5) had more potent inhibitory activities than kojic acid which was used as the reference inhibitor.
