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16502-08-2

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16502-08-2 Usage

General Description

5-Benzyl-[1,3,4]thiadiazol-2-ylamine is a chemical compound with the molecular formula C9H8N4S. It is a member of the thiadiazole family and contains a benzyl group attached to the thiadiazole ring. 5-BENZYL-[1,3,4]THIADIAZOL-2-YLAMINE has been studied for its potential biological and pharmaceutical properties, including its antimicrobial, antiviral, and anti-inflammatory activities. It has also been investigated for its potential use in the development of new drugs for various therapeutic applications. The precise mechanisms of action and specific uses of 5-benzyl-[1,3,4]thiadiazol-2-ylamine are still under investigation, but its unique chemical structure makes it an interesting target for further research and development in the field of medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 16502-08-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,0 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 16502-08:
(7*1)+(6*6)+(5*5)+(4*0)+(3*2)+(2*0)+(1*8)=82
82 % 10 = 2
So 16502-08-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H9N3S/c10-9-12-11-8(13-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,10,12)

16502-08-2Relevant articles and documents

Synthesis of 5-alkyl-2-amino-1,3,4-thiadiazoles and α,ω-bis(2- amino-1,3,4-thiadiazol-5-yl)alkanes in ionic liquids

Epishina, Margarita A.,Kulikov, Alexander S.,Ignat'Ev, Nikolai V.,Schulte, Michael,Makhova, Nina N.

, p. 331 - 333 (2011)

Reaction of thiosemicarbazide with carboxylic acids, including N-substituted amino acids, in ionic liquids with H2SO4 as a catalyst affords 5-R-2-amino-1,3,4-thiadiazoles. On using alkanedicarboxylic acids, α,ω-bis(2-amino-1,3,4,-thiadiazol-5-yl)alkanes were obtained.

-

Klosa

, p. 12 (1954)

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Synthesis of (1,3,4-thiadiazol-2-yl)-acrylamide derivatives as potential antitumor agents against acute leukemia cells

An, Ran,Guo, Chun,Li, Qing,Li, Yan,Wang, Renxiao,Xu, Yaochun,Zhou, Mi

supporting information, (2020/03/25)

A lead compound with the (1,3,4-thiadiazol-2-yl)-acrylamide scaffold was discovered to have significant cytotoxicity on several tumor cell lines in an in-house cell-based screening. A total of 60 derivative compounds were then synthesized and tested in a CCK-8 cell viability assay. Some of them exhibited improved cytotoxic activities. The most potent compounds had IC50 values of 1–5 μM on two acute leukemia tumor cell lines, i.e. RS4;11 and HL-60. Flow cytometry analysis of several active compounds and detection of caspase activation indicated that they induced caspase-dependent apoptosis. It was also encouraging to observe that these compounds did not have obvious cytotoxicity on normal cells, i.e. IC50 > 50 μM on HEK-293T cells. Although the molecular targets of this class of compound are yet to be revealed, our current results suggest that this class of compound represents a new possibility for developing drug candidates against acute leukemia.

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

Han, Yingzhi,Sun, Yadong,Abdukader, Ablimit,Liu, Bifu,Wang, Duozhi

, p. 3486 - 3491 (2018/09/27)

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

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