742060-65-7

Upstream product

• 2592-18-9 N-tert-butoxycarbonyl-L-allo-threonine 
• 100-39-0 benzyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1430098-18-2 C₄₉H₅₈N₄O₉Si 
• 415919-17-4 (4S,5S)-N-(p-methoxybenzyl)-2,2-dioxo-1,2,3-oxathiazolidinone-5-methyl-4-carboxylic acid benzyl ester 
• 415919-16-3 N-(p-methoxybenzyl)-L-allo-threonine benzyl ester 
• 415919-18-5 (4S,5S)-2,2-dioxo-1,2,3-oxathiazolidinone-5-methyl-4-carboxylic acid benzyl ester 
• 88357-80-6 L-allo-Thr(OBn) 

Relevant academic research and scientific papers

Tataricins A and B, two novel cyclotetrapeptides from Aster tataricus, and their absolute configuration assignment

Two novel cyclotetrapeptides, tataricins A and B, with a unique cyclopeptide backbone and aδ 2,4Pro side chain, were isolated from the traditional Chinese medicine Aster tataricus. Their structures and absolute configurations were determined using a combination of spectroscopic data, the advanced Marfey's method, and a total synthesis. Copyright

LYSOBACTIN AMIDES

The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.

Application of serine- and threonine-derived cyclic sulfamidates for the preparation of S-linked glycosyl amino acids in solution- and solid-phase peptide synthesis

Cyclic sulfamidates were synthesized in 60% yield from L-serine and allo-L-threonine, respectively. These sulfamidates reacted with a variety of unprotected 1-thio sugars in aqueous bicarbonate buffer (pH 8) to afford the corresponding S-linked serine- and threonine-glycosyl amino acids with good diastereoselectivity (≥97%) after hydrolysis of the N-sulfates. The serine-derived sulfamidate was incorporated into a simple dipeptide to generate a reactive dipeptide substrate that underwent chemoselective ligation with a 1-thio sugar to afford an S-linked glycopeptide. This sulfamidate was also incorporated into a peptide on a solid support in conjunction with solid-phase peptide synthesis. Chemoselective ligation of a 1-thio sugar with the cyclic sulfamidate was achieved on the solid support, followed by removal of the N-sulfate. Finally, the peptide chain of the resulting support-bound S-linked glycopeptide was extended using standard peptide synthesis procedures.