742071-16-5Relevant academic research and scientific papers
Synthesis and reactivity of α-bromo-4-(difluoromethylthio) acetophenone
Demchenko,Nazarenko,Andrushko,Fediyuk,Krasovsky,Yagupolsky
, p. 965 - 969 (2003)
A synthesis is reported for α-bromo-4-difluoromethylthioacetophenone and the conditions for the condensation of this compound with 2-aminothiazole, 2-amino-5-chloropyridine, 2-amino-4,5-dihydro-3H-pyrrole, benzimidazoline-2- thione, oxadiazoline-2-thione, and thiourea were studied. S- and N-substituted azaheterocycles containing the 4-(difluoromethylthio)phenyl fragment were synthesized and characterized.
Alpha-fluorochalcone derivative and application thereof
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Paragraph 0230-0233, (2021/05/22)
The invention provides an alpha-fluorochalcone derivative and application thereof. The derivative comprises pharmaceutically acceptable salt of the derivative. The invention also provides an application of the derivative and the pharmaceutically acceptable salt thereof in preparation of drugs for treating PPAR receptor related diseases. The derivative provided by the invention has the characteristics of good in-vivo absorption, high bioavailability and strong drug effect, thereby having huge clinical application value.
