742078-81-5Relevant articles and documents
Fluorescence polarization-based assays for detecting compounds binding to inactive c-Jun N-terminal kinase 3 and p38α mitogen-activated protein kinase
Ansideri, Francesco,Lange, Andreas,El-Gokha, Ahmed,Boeckler, Frank M.,Koch, Pierre
, p. 28 - 40 (2016)
Two fluorescein-labeled pyridinylimidazoles were synthesized and evaluated as probes for the binding affinity determination of potential kinase inhibitors to the c-Jun N-terminal kinase 3 (JNK3) and p38α mitogen-activated protein kinase (MAPK). Fluorescen
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis
Revesz, Laszlo,Blum, Ernst,Di Padova, Franco E.,Buhl, Thomas,Feifel, Roland,Gram, Hermann,Hiestand, Peter,Manning, Ute,Rucklin, Gerard
, p. 3595 - 3599 (2007/10/03)
A library of trisubstituted oxazoles, thiazoles, imidazoles (1,2,4- and 2,4,5-substituted) and imidazo[1,2-b]pyridines was prepared and evaluated in vitro as p38α inhibitors and in vivo in several models of rheumatoid arthritis. Four structures - 32, 37,