742078-89-3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 742078-85-9 4-[5-(4-fluoro-phenyl)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazol-4-yl]-2-methylsulfanyl-pyrimidine 
• 204062-82-8 4-(4-Fluorophenyl)-5-(2-methylthio-pyrimidin-4-yl)imidazole 
• 266358-16-1 2-bromo-1-(4-fluorophenyl)-2-(2-methylsulfanylpyrimidin-4-yl)ethanone 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 

Downstream Products

• 742078-93-9 4-[4-(4-fluoro-phenyl)-5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1-methyl-piperidin-4-ol 
• 742078-91-7 4-[4-(4-fluoro-phenyl)-5-(2-methanesulfinyl-pyrimidin-4-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1-methyl-piperidin-4-ol 

Relevant academic research and scientific papers

Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis

A library of trisubstituted oxazoles, thiazoles, imidazoles (1,2,4- and 2,4,5-substituted) and imidazo[1,2-b]pyridines was prepared and evaluated in vitro as p38α inhibitors and in vivo in several models of rheumatoid arthritis. Four structures - 32, 37,