266358-16-1

Upstream product

• 403-33-8 methyl 4-flurobenzoate 
• 14001-63-9 2-methylthio-4-methylpyrimidine 
• 217661-99-9 1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone 

Downstream Products

• 742078-84-8 4-(4-Fluorophenyl)-5-(2-methylthiopyrimidin-4-yl)oxazole 
• 204062-82-8 4-(4-Fluorophenyl)-5-(2-methylthio-pyrimidin-4-yl)imidazole 
• 742078-97-3 4-[4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-oxazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 480453-78-9 [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methanol 
• 1042442-43-2 2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine-7-carboxylic acid ethyl ester 
• 1629240-58-9 2-(4-fluorophenyl)-3-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine 
• 340042-06-0 2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine 
• 1629992-03-5 2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)-7-((trimethylsilyl)ethynyl)imidazo[1,2-a]pyrimidine 
• 742078-93-9 4-[4-(4-fluoro-phenyl)-5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1-methyl-piperidin-4-ol 
• 742078-99-5 4-[5-(2-cyclohexylamino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-oxazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 742078-91-7 4-[4-(4-fluoro-phenyl)-5-(2-methanesulfinyl-pyrimidin-4-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1-methyl-piperidin-4-ol 
• 742078-89-3 4-[4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1-methyl-piperidin-4-ol 
• 742078-98-4 4-[4-(4-fluoro-phenyl)-5-(2-methanesulfinyl-pyrimidin-4-yl)-oxazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 742078-90-6 4-[4-(4-fluoro-phenyl)-5-(2-methanesulfinyl-pyrimidin-4-yl)-oxazol-2-yl]-1-methyl-piperidin-4-ol 

Relevant academic research and scientific papers

Synthesis and biological activity of imidazopyridine anticoccidial agents: Part I

Coccidiosis is the major cause of morbidity and mortality in the poultry industry. Protozoan parasites of the genus Eimeria invade the intestinal lining of the avian host causing tissue pathology, poor weight gain, and in some cases mortality. Resistance

NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Disclosed relates to new substituted 1,3-thiazole derivatives or pharmaceutically acceptable salts thereof having immunosuppresion and inflammation inhibitory activity, intermediate compounds or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The compound of the present invention having excellent TNF-α inhibitory activity and inflammation inhibitory activity can be effectively used in the prevention and treatment of TNF-α related diseases.

Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents

Compounds 10a (IC50 110 pM) and 21 (IC50 40 pM) are the most potent inhibitors of Eimeria tenella cGMP-dependent protein kinase activity reported to date and are efficacious in the in vivo antiparasitic assay when administered to chi

Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents

Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.