74209-22-6

Basic information

• Product Name: 7-CHLORO-5-NITRO-1H-INDAZOLE
• Synonyms: 7-CHLORO-5-NITRO-1H-INDAZOLE;7-Chloro-5-nitro-1H-benzimidazole
• CAS NO: 74209-22-6
• Molecular Formula: C7H4ClN3O2
• Molecular Weight: 197.58
• Mol File: 74209-22-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 251-252 °C(Solv: ethanol (64-17-5))
• Boiling Point: 397.9°C at 760 mmHg
• Flash Point: 194.4°C
• Appearance: /
• Density: 1.661g/cm³
• Vapor Pressure: 3.52E-06mmHg at 25°C
• Refractive Index: 1.742
• PKA: 9?+-.0.40(Predicted)
• CAS DataBase Reference: 7-CHLORO-5-NITRO-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-5-NITRO-1H-INDAZOLE(74209-22-6)
• EPA Substance Registry System: 7-CHLORO-5-NITRO-1H-INDAZOLE(74209-22-6)

Safety Data

• Hazardous Substances Data: 74209-22-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4ClN3O2/c8-6-2-5(11(12)13)1-4-3-9-10-7(4)6/h1-3H,(H,9,10)

Upstream product

• 99-52-5 2-methyl-4-nitro-benzenamine 
• 69951-02-6 2-chloro-6-methyl-4-nitro-phenylamine 
• 108-24-7 acetic anhydride 
• 87-63-8 2-chloro-6-methylaniline 

Relevant articles and documents

Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy

Upon analysis of the reported crystal structure of PAK4 inhibitor KY04031 (PAK4 IC50?=?0.790?μM) in the active site of PAK4, we investigated the possibility of changing the triazine core of KY04031 to a quinazoline. Using KY04031 as a starting

Aromatic Diazonium Salts, X. - A One-Pot Procedure for the Jacobson Synthesis of Indazole

Procedures are described for a one-pot synthesis of 1H-indazole and substituted indazoles 3 in good yield (Table 1) from o-toluidines 2, alkyl nitrite or nitrous oxides, potassium acetate, and acetic anhydride in benzene.The spectroscopic properties of substituted indazoles (Tables 2-4) are discussed. - 4-Phenylcinnoline (18) is prepared by the same procedure from o-(α-methylenebenzyl)aniline.