742099-65-6

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-(N-morpholino)-benzaldehyde is used as a key intermediate in the synthesis of pharmaceutical compounds for [application reason]. Its ability to react with a wide range of reagents enables the creation of diverse and complex structures, contributing to the development of novel therapeutic agents.
Used in Agricultural Chemicals Production:
In the agricultural sector, 5-Bromo-2-(N-morpholino)-benzaldehyde is employed as a building block in the production of agricultural chemicals for [application reason]. Its versatility in forming complex structures aids in the development of effective and targeted agrochemicals.
Used in Dyes Production:
5-Bromo-2-(N-morpholino)-benzaldehyde is utilized as a starting material in the synthesis of dyes for [application reason]. Its yellow solid form and reactivity with various reagents make it suitable for creating a wide range of dye products with different color properties and applications.

InChI:InChI=1/C11H12BrNO2/c12-10-1-2-11(9(7-10)8-14)13-3-5-15-6-4-13/h1-2,7-8H,3-6H2

Upstream product

• 110-91-8 morpholine 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 

Downstream Products

• 742099-66-7 ethyl (2E)-3-(5-bromo-2-morpholin-4-ylphenyl)acrylate 
• 30483-75-1 4-bromophenyl-morpholine 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents

Gram-positive bacteria are among the most common human pathogens associated with clinical infections which range from mild skin infections to sepsis. Resistance towards existing class of drugs by Gram-positive bacteria including methicillin resistant Stap

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.

WDR5 INHIBITORS AND MODULATORS

Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

ACRYLAMIDE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

A compound represented by the formula: wherein R1 is a 5- or 6-membered ring; R3 is a hydrogen atom, a lower alkyl group or a lower alkoxy group; R7 and R8 are each a hydrogen atom or a lower alkyl group; Z1 is another 5- or 6-membered aromatic ring; Z2 is a group represented by -Z2a-W1-Z2b- [wherein Z2a and Z2b are each O, S(O)m (wherein m is 0, 1 or 2), an imino group or a bond, and W1 is an alkylene chain]; X is CR (wherein R is a hydrogen atom, a lower alkyl group, a lower alkoxy group, an acyl group, or R and adjacent R4 may form a 5- or 6-membered alicyclic heterocyclic group) or N; R4 is NR5R6 (wherein R5 and R6 are each a hydrogen atom, a hydrocarbon group, a heterocyclic group or an acyl group), or R5 and R6 are bonded to each other to form a heterocyclic group of NR5R6; and R2 is (1) an amino group which may be a quaternary ammonium or oxide, (2) a nitrogen-containing heterocyclic group which may contain a sulfur atom or an oxygen atom as the ring-constituting atom, in which the nitrogen atom may be converted to a quaternary ammonium or an oxide, or the like; or a salt thereof. The compound has excellent CCR5 antagonistic activity and thus is useful as a prophylactic and/or therapeutic medicine for HIV infection into human peripheral blood monocyte, especially for AIDS.