742104-83-2Relevant academic research and scientific papers
Asymmetric synthesis of a highly functionalized enantioenriched system close to thapsigargin framework
Tap, Aurelien,Galvani, Gilles,Sorin, Geoffroy,Lannou, Marie-Isabelle,Ardisson, Janick,Jouanneau, Morgan,Ferezou, Jean-Pierre
, p. 8140 - 8146,7 (2012)
A straightforward approach to a highly functionalized enantioenriched bicyclo[5.3.0]decadienone system close to the thapsigargin framework has been achieved. The developed synthetic route involves two main stages: installation of the chains on either side of the quaternary center at C7 starting from a central enantiopure epoxide and formation of the bicyclic octahydroazulene through subsequent Pauson-Khand annelation.
PROTEIN KINASE C AGONISTS
-
, (2020/09/12)
The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions dis
PROTEIN KINASE C AGONISTS
-
, (2020/09/12)
The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by protein kinase C (PKC) agonists, such as HIV.
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones
Kang, Ji-Hye,Siddiqui, Maqbool A.,Sigano, Dina M.,Krajewski, Krzysztof,Lewin, Nancy E.,Pu, Yongmei,Blumberg, Peter M.,Lee, Jeewoo,Marquez, Victor E.
, p. 2413 - 2416 (2007/10/03)
(Equation Presented) Commercially available 2-methylenepropane-1,3-diol was converted to chiral epoxide (R)-2 via Sharpless asymmetric epoxidation in >96% ee. Regiospecific epoxide ring opening and reduction of the intermediate alkyne set the stage for a
