742106-24-7Relevant articles and documents
High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme
Cancio, Reynel,Silvestri, Romano,Ragno, Rino,Artico, Marino,De Martino, Gabriella,La Regina, Giuseppe,Crespan, Emmanuele,Zanoli, Samantha,Huebscher, Ulrich,Spadari, Silvio,Maga, Giovanni
, p. 4546 - 4554 (2005)
Indolyl aryl sulfone (IAS) nonnucleoside inhibitors have been shown to potently inhibit the growth of wild-type and drug-resistant human immunodeficiency virus type 1 (HIV-1), but their exact mechanism of action has not been elucidated yet. Here, we descr
Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations
Silvestri, Romano,Artico, Marino,De Martino, Gabriella,La Regina, Giuseppe,Loddo, Roberta,La Colla, Massimiliano,La Colla, Paolo
, p. 3892 - 3896 (2007/10/03)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) active against NNRTI-resistant mutants were obtained by introducing two methyl groups at positions 3 and 5 of the benzenesulfonyl moiety of L-737,126 (1) and coupling one to three glycinamide/alanin
