742119-96-6

Basic information

• Product Name: C₁₅H₁₁N₃O₄
• Synonyms: C₁₅H₁₁N₃O₄
• CAS NO: 742119-96-6
• Molecular Weight: 297.27
• Mol File: 742119-96-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₁N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₁N₃O₄(742119-96-6)
• EPA Substance Registry System: C₁₅H₁₁N₃O₄(742119-96-6)

Safety Data

• Hazardous Substances Data: 742119-96-6(Hazardous Substances Data)

Upstream product

• 42059-81-4 3-formyl-6-methylchromone 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 

Relevant articles and documents

Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-α and IL-6 inhibitors

In the present article, we have synthesized three different series of pyrazolo[3,4-b]pyridines and their structural analogues using novel synthetic strategy involving one-pot condensation of 5,6-dihydro-4H-pyran-3-carbaldehyde/2-formyl-3,4,6-tri-O-methyl-d-glucal /chromone-3-carbaldehyde with heteroaromatic amines. All synthesized compounds were evaluated for their anti-inflammatory activity against TNF-α and IL-6. Out of 28 compounds screened, 40, 51, 52 and 56 exhibited promising activity against IL-6 with 60-65% inhibition at 10 μM concentration. Amongst these, 51, 52 and 56 showed potent IL-6 inhibitory activity with IC50's of 0.2, 0.3 and 0.16 μM, respectively. Compound 56 was not cytotoxic in CCK-8 cells up to the concentration of >100 μM.