74212-41-2Relevant academic research and scientific papers
Metal-Free meta-Selective Alkyne Oxyarylation with Pyridine N-Oxides: Rapid Assembly of Metyrapone Analogues
Chen, Xiangyu,Ruider, Stefan A.,Hartmann, Rolf W.,González, Leticia,Maulide, Nuno
supporting information, p. 15424 - 15428 (2016/12/03)
An efficient metal-free oxyarylation of electron-poor alkynes with pyridine N-oxides has been developed. This transformation affords meta-substituted pyridines analogous to the drug metyrapone in high regioselectivities. Density functional theory (DFT) ca
MEDICINAL COMPOSITIONS
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, (2008/06/13)
The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.
Adenosine A3 receptor antagonists
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, (2008/06/13)
A pharmaceutical composition for antagonizing adenosine at adenosine A3receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.
5-pyridyl-1,3-thiazole derivatives
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, (2008/06/13)
Novel compounds of the formula: STR1 wherein R1 stands for an optionally substituted alkyl group, alkenyl group, aryl group, aralkyl group, cycloalkyl group, heterocyclic group having carbon as the bonding hand or amino group, R2 stands for a pyridyl group which may be substituted with alkyl group, and R3 stands for an optionally substituted aryl group or salts thereof, have analgesic, anti-piretic, anti-inflammatory and anti-ulcer actions, and can be administered to mammals for the therapy of pain, inflammatory diseases, rheumatic chronic diseases.
Conversion of Pyridines and Quinolines into Pyridazines and Pyrazoles
Baradarani, M. Mehdi,Joule, John A.
, p. 72 - 77 (2007/10/02)
3-Phenacylpyridinium and 3-phenacylquinolinium methiodides are shown to react with hydrazine-potassium hydroxide and hydrazine respectively to give 4-alkyl-6-phenylpyridazines and 4-(2-aminobenzyl)-6-phenylpyridazines respectively. 3-Benzoylpyridinium met
