74222-81-4

Basic information

• Product Name: 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-dioxolane
• Synonyms: 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-dioxolane
• CAS NO: 74222-81-4
• Molecular Weight: 278.392
• Mol File: 74222-81-4.mol

Chemical Properties

• CAS DataBase Reference: 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-dioxolane(74222-81-4)
• EPA Substance Registry System: 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-dioxolane(74222-81-4)

Safety Data

• Hazardous Substances Data: 74222-81-4(Hazardous Substances Data)

Upstream product

• 107-21-1 ethylene glycol 
• 1620-98-0 3,5-di-t-butyl-4-hydroxybenzaldehyde 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 

Downstream Products

• 223579-57-5 (E)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-(N-methoxymethyl-N-benzyloxycarbamoyl)-1,2-isothiazolidine-1,1-dioxide 
• 223579-40-6 (3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-[2-(4-methoxy-benzyl)-1,1-dioxo-1λ⁶-isothiazolidin-5-yl]-methanol 
• 223579-49-5 [2-(4-chloro-phenyl)-1,1-dioxo-1λ⁶-isothiazolidin-5-yl]-(3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-methanol 
• 223579-36-0 (2-benzyloxy-1,1-dioxo-1λ⁶-isothiazolidin-5-yl)-(3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-methanol 
• 279669-73-7 2,6-di-tert-butyl-4-[2-(4-methoxy-benzyl)-1,1-dioxo-1λ⁶-isothiazolidin-5-ylidenemethyl]-phenol 
• 223579-52-0 (3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-(1,1-dioxo-2-pyridin-3-yl-1λ⁶-isothiazolidin-5-yl)-methanol 
• 223579-55-3 (3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-(1,1-dioxo-2-pyridin-4-yl-1λ⁶-isothiazolidin-5-yl)-methanol 
• 223579-50-8 (3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-(1,1-dioxo-2-pyridin-2-yl-1λ⁶-isothiazolidin-5-yl)-methanol 
• 158090-21-2 {5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(E)-ylidene]-1,1-dioxo-1λ⁶-isothiazolidin-2-yl}-acetic acid ethyl ester 
• 279669-71-5 (3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-(1,1-dioxo-2-propyl-1λ⁶-isothiazolidin-5-yl)-methanol 
• 223579-30-4 (2-cyclopropyl-1,1-dioxo-1λ⁶-isothiazolidin-5-yl)-(3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-methanol 
• 223579-27-9 (3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-(2-isobutyl-1,1-dioxo-1λ⁶-isothiazolidin-5-yl)-methanol 
• 279669-74-8 4-(2-benzyloxy-1,1-dioxo-1λ⁶-isothiazolidin-5-ylidenemethyl)-2,6-di-tert-butyl-phenol 

Relevant articles and documents

Development of one-pot synthesis of new antiarthritic drug candidate S-2474 with high E-selectivity

A one-pot synthesis of S-2474 was developed to overcome the problems of a large number of steps, low stereoselectivity, low yield, a large amount of waste, and severe reaction conditions. Aldol-type condensation of 3,5-di-terf-butyl-4-hydroxybenzaldehyde and iV-ethyl-γsultam was carried out with LDA and then quenched with water. Dehydration proceeded under basic conditions, providing S-2474 directly as a single isomer on the benzylidene double bond. The reaction mechanism appears to involve a quinone methide intermediate. Environmental assessment of the development of this compound is also discussed in this paper.

Synthesis and characterization of BHT-derived tert-butyl dendrons

(Chemical Equation Presented) A series of 3,5-poly(aryl ether) dendrons was prepared up to the third generation using inexpensive 3,5-di-tert-butyl-4- hydroxytoluene (BHT, 1) as a starting material.

Novel antiarthritic agents with 1,2-isothiazolidine-1-,1-dioxide (γ- sultam) skeleton: Cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase

Various 1,2-isothiazolidine-1,1-dioxide (γ-sultam) derivatives containing an antioxidant moiety, 2,6-di-tert-butylphenol substituent, were prepared. Some compounds, which have a lower alkyl group at the 2-position of the γ-sultam skeleton, showed potent i