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380607-77-2

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380607-77-2 Usage

Description

CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2. It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively). CMPDA (10 μM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well as slows the rate of deactivation of GluA2o, but not GluA2i, receptors, in HEK293 cells.

Check Digit Verification of cas no

The CAS Registry Mumber 380607-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,0,6,0 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 380607-77:
(8*3)+(7*8)+(6*0)+(5*6)+(4*0)+(3*7)+(2*7)+(1*7)=152
152 % 10 = 2
So 380607-77-2 is a valid CAS Registry Number.

380607-77-2Downstream Products

380607-77-2Relevant articles and documents

Sulfonamide derivatives

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Page 19, (2010/11/30)

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders

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