74247-55-5

Usage

Antiviral properties

Acyclovir has antiviral properties, meaning it is effective in treating infections caused by viruses.

Treatment for herpes virus infections

Acyclovir is commonly used to treat infections caused by herpes viruses, such as genital herpes, cold sores, and shingles.

Mechanism of action

Acyclovir works by inhibiting the replication of viral DNA, which prevents the spread and growth of the virus.

Administration methods

The drug can be administered orally, topically, or intravenously, depending on the specific infection and severity.

Tolerability

Acyclovir is generally well-tolerated, with few side effects in most individuals.

Adverse reactions

Acyclovir may cause adverse reactions in individuals with compromised immune systems or kidney problems.

Effectiveness

Acyclovir is a widely used and effective medication for the treatment of herpes virus infections.

Upstream product

• 74247-54-4 1-(1,6-dihydro-6-thioxopurin-9-yl)-1-S-methyl-1-thio-D-glycero-D-ido-hexitol 
• 74-88-4 methyl iodide 
• 74247-51-1 2,3,4,5,6-penta-O-acetyl-1-(6-chloropurin-9-yl)-1-S-methyl-1-thio-D-glycero-D-ido-hexitol 
• 74247-53-3 2,3,4,5,6-penta-O-acetyl-1-(1,6-dihydro-6-thioxopurin-9-yl)-1-S-methyl-1-thio-D-glycero-D-ido-hexitol 

Downstream Products

• 74247-57-7 2,3,4,5,6-penta-O-acetyl-1-S-methyl-1-(6-methylthiopurin-9-yl)-1-thio-D-glycero-D-ido-hexitol 

Relevant academic research and scientific papers

ACYCLIC-SUGAR PURINE NUCLEOSIDES DERIVED FROM D-GLUCOSE: STEREOCHEMICAL CORRELATIONS IN ACYCLIC-SUGAR DERIVATIVES UNEQUALLY SUBSTITUTED AT C1

Condensation of 2,3,4,5,6-penta-O-acetyl-1-bromo-1-S-methyl-1-thio-D-glucitol (1) with 6-chloro-9-(chloromercuri)purine gave 49percent of crystalline, levorotatory (1S)-2,3,4,5,6-penta-O-acetyl-1-(6-chloropurin-9-yl)-1-S-methyl-1-thio-D-glucitol (3), together with a smaller proportion of the syrupy, dextrorotatory (1R) isomer.Thiourea converted 3 into its 6-mercaptopurine analog, whose O-deacetylated derivative could be S-methylated to the corresponding 6-(methylthio)purin-9-yl analog: all compounds in this sequence were crystalline and were the pure (1S) isomers, as were the corresponding 1'-S-ethyl derivatives prepared by a similar route.Crystal-structure analysis of the O-deacetylated derivative of the 1'-S-ethyl analog of 3 established the relative stereochemistry of the ethyltio group, permitting assignment of the (1S) absolute stereochemistry to this compound and thus to all compounds in the sequence starting from 1, including the previously described, crystalline, levorotatory 1-(1,6-dihydro-6-thioxopurin-9-yl)-1-S-ethyl-1-thio-D-glucitol, whose chirality at C-1 had not hitherto been established.The close similarity of the chiroptical properties of the crystalline 1'-S-methyl derivatives to those of their 1'-S-ethyl counterparts permitted firm attribution of (1S) chirality to the former series also.Conformational studies showed that all of the derivatives have the sugar chain in a non-extended (sickle) conformation.