74247-57-7

Usage

Uses

Used in Cancer Therapy:
2,3,4,5,6-penta-O-acetyl-1-S-methyl-1-C-[6-(methylsulfanyl)-9H-purin-9-yl]-1-thiohexitol is used as a potential therapeutic agent in cancer treatment. Its unique chemical structure allows it to modulate RNA structures and function, which can be leveraged to target cancer cells and inhibit their growth and proliferation.
Used in Biochemical Research:
In the field of biochemical research, 2,3,4,5,6-penta-O-acetyl-1-S-methyl-1-C-[6-(methylsulfanyl)-9H-purin-9-yl]-1-thiohexitol serves as a valuable tool for studying nucleic acid interactions. Its modified structure enables researchers to gain insights into the mechanisms of RNA regulation and the development of novel therapeutic strategies.
Used in Drug Development:
2,3,4,5,6-penta-O-acetyl-1-S-methyl-1-C-[6-(methylsulfanyl)-9H-purin-9-yl]-1-thiohexitol is utilized in drug development to create new therapeutic agents that target RNA molecules. Its unique properties and potential to modulate RNA structures make it a promising candidate for the development of innovative drugs with specific applications in various diseases, including cancer.
Used in Pharmaceutical Industry:
2,3,4,5,6-penta-O-acetyl-1-S-methyl-1-C-[6-(methylsulfanyl)-9H-purin-9-yl]-1-thiohexitol is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique chemical structure and potential applications in cancer therapy and drug development make it a valuable component in the development of novel drugs with improved efficacy and selectivity.
Used in Diagnostic Applications:
In the diagnostic industry, 2,3,4,5,6-penta-O-acetyl-1-S-methyl-1-C-[6-(methylsulfanyl)-9H-purin-9-yl]-1-thiohexitol can be employed as a molecular probe or a diagnostic marker. Its ability to interact with nucleic acids and modulate RNA structures can be utilized to develop diagnostic tools for detecting and monitoring various diseases, including cancer.

Upstream product

• 108-24-7 acetic anhydride 
• 74247-55-5 1-S-methyl-1-(6-methylthiopurin-9-yl)-1-thio-D-glycero-D-ido-hexitol 

Relevant academic research and scientific papers

ACYCLIC-SUGAR PURINE NUCLEOSIDES DERIVED FROM D-GLUCOSE: STEREOCHEMICAL CORRELATIONS IN ACYCLIC-SUGAR DERIVATIVES UNEQUALLY SUBSTITUTED AT C1

Condensation of 2,3,4,5,6-penta-O-acetyl-1-bromo-1-S-methyl-1-thio-D-glucitol (1) with 6-chloro-9-(chloromercuri)purine gave 49percent of crystalline, levorotatory (1S)-2,3,4,5,6-penta-O-acetyl-1-(6-chloropurin-9-yl)-1-S-methyl-1-thio-D-glucitol (3), together with a smaller proportion of the syrupy, dextrorotatory (1R) isomer.Thiourea converted 3 into its 6-mercaptopurine analog, whose O-deacetylated derivative could be S-methylated to the corresponding 6-(methylthio)purin-9-yl analog: all compounds in this sequence were crystalline and were the pure (1S) isomers, as were the corresponding 1'-S-ethyl derivatives prepared by a similar route.Crystal-structure analysis of the O-deacetylated derivative of the 1'-S-ethyl analog of 3 established the relative stereochemistry of the ethyltio group, permitting assignment of the (1S) absolute stereochemistry to this compound and thus to all compounds in the sequence starting from 1, including the previously described, crystalline, levorotatory 1-(1,6-dihydro-6-thioxopurin-9-yl)-1-S-ethyl-1-thio-D-glucitol, whose chirality at C-1 had not hitherto been established.The close similarity of the chiroptical properties of the crystalline 1'-S-methyl derivatives to those of their 1'-S-ethyl counterparts permitted firm attribution of (1S) chirality to the former series also.Conformational studies showed that all of the derivatives have the sugar chain in a non-extended (sickle) conformation.