74249-17-5

Basic information

• Product Name: 2-(2-FLUOROPHENYL)OXIRANE
• Synonyms: 2-(2-FLUOROPHENYL)OXIRANE
• CAS NO: 74249-17-5
• Molecular Formula: C8H7FO
• Molecular Weight: 138.14
• Mol File: 74249-17-5.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-FLUOROPHENYL)OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUOROPHENYL)OXIRANE(74249-17-5)
• EPA Substance Registry System: 2-(2-FLUOROPHENYL)OXIRANE(74249-17-5)

Safety Data

• Hazardous Substances Data: 74249-17-5(Hazardous Substances Data)

Usage

Physical State

Colorless liquid

Molecular Weight

138.14 g/mol

Usage

Building block for the synthesis of various organic compounds in pharmaceutical and agrochemical industries, intermediate in the production of other chemicals, and potential applications in materials science.

Reactivity

Unique structure and reactivity

Safety Precautions

Potential health hazards require careful handling and proper safety measures.

Upstream product

• 394-46-7 2-fluorostyrene 
• 1030268-21-3 trimethylsulfonium iodide 
• 446-52-6 2-Fluorobenzaldehyde 
• 53688-17-8 2-chloro-1-(fluorophenyl)-ethanone 
• 389-31-1 R-ortho-fluoromandelic acid 
• 1774-47-6 trimethylsulfoxonium iodide 
• 6814-64-8 methylenedimethyl sulfurane 
• 937-14-4 3-chloro-benzenecarboperoxoic acid 

Downstream Products

• 1133819-85-8 5-{4-[2-(2-fluorophenyl)-2-oxoethoxy]benzyl}-1,3-thiazolidine-2,4-dione 
• 1133820-02-6 5-{4-[2-(2-fluorophenyl)-2-hydroxyethoxy] benzyl}-1,3-thiazolidine-2,4-dione 
• 1133820-01-5 5-{4-[2-(2-fluorophenyl)-2-hydroxyethoxy]benzylidene}-1,3-thiazolidine-2,4-dione 

Relevant articles and documents

Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade

Enantioenriched azido alcohols are precursors for valuable chiral aziridines and 1,2-amino alcohols, however their chiral substituted analogues are difficult to access. We established a cascade for the asymmetric azidohydroxylation of styrene derivatives leading to chiral substituted 1,2-azido alcohols via enzymatic asymmetric epoxidation, followed by regioselective azidolysis, affording the azido alcohols with up to two contiguous stereogenic centers. A newly isolated two-component flavoprotein styrene monooxygenase StyA proved to be highly selective for epoxidation with a nicotinamide coenzyme biomimetic as a practical reductant. Coupled with azide as a nucleophile for regioselective ring opening, this chemo-enzymatic cascade produced highly enantioenriched aromatic α-azido alcohols with up to >99% conversion. A bi-enzymatic counterpart with halohydrin dehalogenase-catalyzed azidolysis afforded the alternative β-azido alcohol isomers with up to 94% diastereomeric excess. We anticipate our biocatalytic cascade to be a starting point for more practical production of these chiral compounds with two-component flavoprotein monooxygenases.

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases

The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).