74257-00-4

Usage

Uses

Used in Molecular Biology and Biotechnology:
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole is used as a coupling reagent for the synthesis of phosphotriester oligonucleotides. Its application is crucial in the development of novel molecular biology techniques and the creation of advanced biotechnological products.
Used in Oligonucleotide Synthesis:
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole is used as an efficient coupling reagent in the phosphotriesters approach to oligonucleotide synthesis. This method allows for the formation of high-quality and stable oligonucleotides, which are essential for various research and therapeutic applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole may be utilized as a key component in the development of new drugs and drug delivery systems, particularly those involving nucleic acid-based therapies.
Used in Research and Development:
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole is also used in research and development laboratories, where it contributes to the advancement of scientific knowledge and the discovery of innovative solutions in molecular biology and related fields.

InChI:InChI=1/C11H12N4O4S/c1-7-4-8(2)10(9(3)5-7)20(18,19)14-6-12-11(13-14)15(16)17/h4-6H,1-3H3

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 24807-55-4 3-nitro-1,2,4-triazole 

Downstream Products

• 76991-94-1 C₄₀H₂₉N₉O₁₀ 
• 76887-35-9 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-benzoylamino-6-(3-nitro-[1,2,4]triazol-1-yl)-purin-9-yl]-tetrahydro-furan-3-yl ester 
• 76859-60-4 Acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(2,4,6-trimethyl-benzenesulfonyloxymethyl)-tetrahydro-furan-3-yl ester 
• 76887-37-1 4-(3-nitro-1,2,4-triazol-1-yl)-1-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-pyrimedin-2(1H)-one 
• 191086-85-8 Acetic acid (dimethyl-{3-[4-(3-nitro-[1,2,4]triazol-1-yl)-2-oxo-2H-pyrimidin-1-yl]-propyl}-silanyl)-methyl ester 
• 191086-84-7 Acetic acid (acetoxymethyl-methyl-{3-[4-(3-nitro-[1,2,4]triazol-1-yl)-2-oxo-2H-pyrimidin-1-yl]-propyl}-silanyl)-methyl ester 
• 127940-28-7 2,3:5,6-di-O-isopropylidene-D-myo-inositol-1-O-mesitylenesulphonate 
• 110434-88-3 2,3,4,6,1',3',6'-Hepta-O-acetyl-4'-O-(mesitylensulfonyl)sucrose 
• 110507-86-3 (2,3,4,6,1',3',6'-Hepta-O-acetylsucrose-4')(exo-benzyl-3,4-O-benzyliden-β-L-arabinopyranosid-2)(2,2,2-trichlorethyl)phosphat 
• 110434-90-7 exo-Benzyl-3,4-O-benzyliden-2-O-mesitylensulfonyl-β-L-arabinopyranosid 
• 110507-85-2 (2,3,4,6,1',3',6'-Hepta-O-acetylsucrose-4')(exo-benzyl-3,4-O-benzyliden-β-L-arabinopyranosid-2)(2,2,2-trichlorethyl)phosphat 
• 76887-39-3 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-[2-benzoylamino-6-(3-nitro-[1,2,4]triazol-1-yl)-purin-9-yl]-tetrahydro-furan-3-yl ester 
• 132885-38-2 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-4-(3-nitro-1,2,4-triazol-1-yl)-5-methyl-6-(phenylthio)pyrimidin-2-one 
• 132885-40-6 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-4-(3-nitro-1,2,4-triazol-1-yl)-6-(phenylthio)pyrimidin-2-one 

Relevant academic research and scientific papers

HIGHLY REACTIVE CONDENSING AGENTS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES BY THE PHOSPHOTRIESTER APPROACH

4,6-Dinitro-1-(mesitylene-2-sulphonyloxy)-benzotriazole , 1-(mesitylene-2-sulphonyloxy)-4-nitro-6-trifluoromethylbenzotriazole (6a) and 1-(mesitylene-2-sulphonyl)-4-nitro-1,2,3-triazole are more reactive condensing agents in the phosphotriester approach to oligonucleotide synthesis than 1-(mesitylene-2-sulphonyl)-3-nitro-1,2,4-triazole by factors of at least 10, ca. 4 and ca. 1.3, respectively.