7426-75-7

Usage

Uses

Used in Polymer Industry:
1,4-Bis(4,5-dihydro-2-oxazolyl)benzene is used as a crosslinking agent for improving the mechanical and thermal properties of thermoset polymers, making them more resistant to heat and wear.
Used in Plastics Production:
It serves as a stabilizer in the production of various plastic products, contributing to their durability and performance.
Used in Pharmaceutical and Agrochemical Synthesis:
1,4-Bis(4,5-dihydro-2-oxazolyl)benzene is utilized in the synthesis of pharmaceuticals and agrochemicals, playing a crucial role in the development of new compounds with therapeutic or agricultural applications.
Used in Adhesives, Coatings, and Sealants Production:
1,4-Bis(4,5-dihydro-2-oxazolyl)benzene is also used in the production of adhesives, coatings, and sealants, enhancing their bonding and sealing capabilities.
Safety Note:
It is important to handle 1,4-Bis(4,5-dihydro-2-oxazolyl)benzene with caution due to its skin and eye irritant properties. Proper safety measures should be taken during its use to minimize potential health risks.

InChI:InChI=1/C12H12N2O2/c1-2-10(12-14-6-8-16-12)4-3-9(1)11-13-5-7-15-11/h1-4H,5-8H2

Upstream product

• 926-39-6 sulfuric acid mono-(2-amino-ethyl ester) 
• 100-20-9 terephthaloyl chloride 
• 106833-89-0 Terephthalic acid bis-N-(2-hydroxyethyl)amide acid sulfate 
• 18928-62-6 Terephthalic acid bis-N-(2-hydroxyethyl)amide 
• 623-26-7 terephthalonitrile 
• 141-43-5 ethanolamine 
• 623-27-8 terephthalaldehyde, 
• 41526-99-2 4-(4,5-dihydrooxazol-2-yl) benzonitrile 
• 636-09-9 diethyl terephthalate 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 100-21-0 terephthalic acid 
• 40651-60-3 N,N'-bis-(2-chloro-ethyl)-terephthalamide 

Downstream Products

• 18126-24-4 2,2'-bisethanol 
• 51124-38-0 4,5,4',5'-tetrahydro-2,2'-cyclohexane-1,4-diyl-bis-oxazole 
• 51575-77-0 1,4-Phenylene-2,2'-bisoxazole 

Relevant academic research and scientific papers

A 2 - substituted oxazoline or 2 - substituted piperazine synthetic method (by machine translation)

The invention discloses a method for synthesizing 2 - substituted oxazoline or 2 - substituted oxazine new method, by nitrile and amino ethanol or 3 - amino - 1 - propanol as raw material, in the absence of solvent, can be used for the recycling of the sulfur to induce synthesis of 2 - substituted oxazoline and 2 - substituted piperazine. The method of the invention has low cost, simple reaction process, mild reaction conditions, the reaction time is short, the yield and the like, is suitable for the industrial generation. (by machine translation)

Ruthenium(II) 9,10-phenanthrenequinone thiosemicarbazone complexes: Synthesis, characterization, and catalytic activity towards the reduction as well as condensation of nitriles

The ligands 9,10-phenanthrenequinone-N4-substituted thiosemicarbazones (HL1-3) and their ruthenium(II) complexes were synthesized and characterized by elemental and spectroscopic methods. The ligands are tridentate, monobasic chelating ligands with O, N, and S as the donor sites and are in the thiol form in all the complexes. Catalytic studies showed that all the complexes displayed good catalytic activity towards the reduction of nitriles and also the condensation of nitriles with 2-aminoalcohol under solvent-free conditions.

Copper N-Heterocyclic Carbene Complexes As Active Catalysts for the Synthesis of 2-Substituted Oxazolines from Nitriles and Aminoalcohols

The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper-NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than those of previously reported methods.

Synthesis of 2-aryl/heteroaryloxazolines from nitriles under metaland catalyst-free conditions and evaluation of their antioxidant activities

The synthesis of structurally diverse 2-aryl/heteroaryloxazolines from nitriles and aminoalcohols has been achieved under metal- and catalyst-free conditions in good to excellent yields. An array of functional groups are well-tolerated, thus, allowing the introduction of many important biologically active motifs such as azoles, ring-fused azoles, saturated heterocyclics, and amines in 2-aryloxazoline scaffolds. An evaluation of the antioxidant properties using the DPPH (diphenyl picryl hydrazyl) assay method shows the pyrrole-functionalized 2-aryloxazoline to be the best antioxidant among all the synthesized 2-aryl/heteroaryloxazolines.

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

S-Co(II) cascade catalysis: Cyclocondensation of aromatic nitriles with alkamine

A solvent-free S/Co(NO3)2 cascade catalyzed cyclocondensation reaction of aromatic nitriles with 3-amino-1-propanol or 2-aminoethanol has been successfully developed under thermal and microwave conditions. By this two-component protocol, mono- and bis-oxazines and oxazolines were selectively synthesized both in good to excellent yields and short reaction times. This catalytic system exhibits excellent chemoselectivity, and can be reused at least seven times without significant loss of activity in subsequent reactions.

Trichloroisocyanuric acid as an efficient homogeneous catalyst for the chemoselective synthesis of 2-substituted oxazolines, imidazolines and thiazolines under solvent-free condition

Trichloroisocyanuric acid, as a commercially available and inexpensive catalyst, was used in a new, facile and efficient procedure for the synthesis of 2-oxazolines, 2-imidazolines and 2-thiazolines through the reaction of nitriles with 2-aminoethanol, ethylenediamine or 2-aminoethanethiol under solvent-free conditions.

A convenient synthesis of 2-oxazolines and 2-benoxazoles with PPh3-DDQ as the dehydrating reagent

2-Oxazolines and 2-benoxazoles were synthesized in high yields from acylamino alcohols and acylaminophenols, respectively, with triphenylphosphine- 2,3-dichloro-5,6-dicyanobenzoquinone (PPh3-DDQ) as the dehydrating and activating reagent. The synthesis was accomplished under neutral conditions.

Preparation of an improved sulfonated carbon-based solid acid as a novel, efficient, and reusable catalyst for chemoselective synthesis of 2-oxazolines and bis-oxazolines

A highly sulfonated carbon as an efficient, recyclable, nontoxic, and green solid acid catalyst was readily synthesized by simultaneous sulfonation, dehydration, and carbonization of sucrose in sulfuric acid and was characterized by FT-IR, TG-DTG, XRD, and CHNS analysis, neutralization potentiometric titration, and SEM techniques. This new catalyst was used for preparation of 2-oxazolines and bis-oxazolines by reaction of β-aminoethanol with nitriles under reflux conditions. Sonication of this system enhanced the catalytic activity of the carbon-based solid acid and led to higher product yields and shorter reaction times. Another advantage of the system under ultrasonic irradiation is the ability to carry out large-scale reactions. In two cases, the catalyst was reused several times without loss of its activity.

A facile synthesis of 2-oxazolines using a PPh3-DDQ system

A facile and efficient synthesis of 2-oxazolines from N-(2-hydroxyethyl)amides using a triphenylphosphine-2,3-dichloro-5,6-dicyanobenzoquinone (PPh3-DQQ) system is described. The reaction proceeds under neutral and mild conditions, and excellent yields are obtained.