74270-30-7

Usage

Uses

Used in Pharmaceutical Industry:
[(4-methylphenoxy)carbonyl]phosphonic acid is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its ability to modify and functionalize organic molecules makes it a valuable compound in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, [(4-methylphenoxy)carbonyl]phosphonic acid is used as a building block for the development of new agrochemicals. Its unique reactivity allows for the creation of novel compounds with potential applications in pest control, crop protection, and other agricultural areas.
Used in Materials Science:
[(4-methylphenoxy)carbonyl]phosphonic acid is employed as a chemical intermediate in the field of materials science. Its potential applications include the development of new materials with specific properties, such as improved strength, durability, or chemical resistance.
Used in Organic Synthesis:
As a versatile building block in organic synthesis, [(4-methylphenoxy)carbonyl]phosphonic acid is used to create a wide range of specialty chemicals. Its unique chemical structure and reactivity enable the synthesis of complex molecules for various applications across different industries.

Upstream product

• 72304-75-7 dimethyl (phenoxycarbonyl)phosphonate 
• 67605-36-1 bis-trimethylsilyl (methoxycarbonyl)phosphonate 
• 2857-97-8 trimethylsilyl bromide 
• 1885-14-9 phenyl chloroformate 

Relevant academic research and scientific papers

Metal-cation-mediated hydrolysis of phosphonoformate diesters: Chemoselectivity and catalysis

Hydrolyses in D2O (pD 1.7-3.1) of dimethyl (7), methyl phenyl (8), phenyl methyl (9), and diphenyl (10) phosphonoformate diesters are substantially accelerated by Ce(IV), Th(IV), Zr(IV), and Hf(IV) cations. Chemoselectivity is observed, whereby

Acyloxymethyl and 4-acyloxybenzyl diester prodrugs of phosphonoformate

Sodium pivaloyloxymethyl (pivaloyloxymethoxycarbonyl)phosphonate 4, sodium 4-acyloxybenzyl phenoxycarbonylphosphonates 14a-c and sodium 4-acyloxybenzyl benzyloxycarbonylphosphonates 15a,b have been prepared as bioreversible prodrugs of the antiviral phosphonoformate 1. Their hydrolyses, in vivo systemic bioavailability and antiviral activity are reported. Of the compounds evaluated 4 was the best prodrug.

PHOSPHONOFORMIC ACID ESTERS

A compound of the formula, wherein R1, R2 and R3 are the same or different, and each is selected from the group consisting of hydrogen and phenyl groups of the formula, wherein R4 and R5 are the same or different and each is selected from the group consis

Synthesis of esters of phosphonoformic acid and their antiherpes activity

Aliphatic and aromatic mono-, di-, and triesters of phosphonoformic (foscarnet) were synthesized. The triesters were prepared by the Michaelis-Arbuzov reaction and were hydrolyzed to di- and monoesters. The compounds were tested for antiviral activity on isolated herpes simplex virus type 1 (HSV-1) DNA polymerase, in a HSV-1 plaque reduction assay, and on a cutaneous HSV-1 infection in guinea pigs. None of the esters inhibited the activity of isolated HSV-1 polymerases. Monoesters with a free carboxylic group and diesters with an aromatic carboxylic ester function were active against the cutaneous herpesa infection. Mono- and diesters with an aromatic phosphonic ester group also showed activity in the plaque-reduction assay. However, mono- and diesters with aliphatic carboxylic ester groups were inactive in all test systems. The results show that all three acidic groups of phosphonoformic acid must be free in order to get antiviral activity at the enzyme level. However, certain esters of this acid may be biotransformed to the acid itself to give antiherpes activity.