72304-75-7

Basic information

• Product Name: phenyl dimethoxyphosphanecarboxylate oxide
• Synonyms: phosphoranecarboxylic acid, 1,1-dimethoxy-, phenyl ester, oxide
• CAS NO: 72304-75-7
• Molecular Formula: C₉H₁₁O₅P
• Molecular Weight: 230.1544
• Mol File: 72304-75-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 284.8°C at 760 mmHg
• Flash Point: 140°C
• Density: 1.275g/cm³
• Vapor Pressure: 0.0029mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: phenyl dimethoxyphosphanecarboxylate oxide(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl dimethoxyphosphanecarboxylate oxide(72304-75-7)
• EPA Substance Registry System: phenyl dimethoxyphosphanecarboxylate oxide(72304-75-7)

Safety Data

• Hazardous Substances Data: 72304-75-7(Hazardous Substances Data)

Upstream product

• 1885-14-9 phenyl chloroformate 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 74270-30-7 disodium phenoxycarbonylphosphonate 
• 74-87-3 methylene chloride 
• 119930-41-5 C₈H₈ClO₄P 
• 791-28-6 Triphenylphosphine oxide 
• 83877-29-6 methyl phenoxycarbonylphosphonate sodium salt 
• 56317-55-6 sodium methyl hydrogen phosphite 
• 868-85-9 Dimethyl phosphite 

Relevant articles and documents

Metal-cation-mediated hydrolysis of phosphonoformate diesters: Chemoselectivity and catalysis

Hydrolyses in D2O (pD 1.7-3.1) of dimethyl (7), methyl phenyl (8), phenyl methyl (9), and diphenyl (10) phosphonoformate diesters are substantially accelerated by Ce(IV), Th(IV), Zr(IV), and Hf(IV) cations. Chemoselectivity is observed, whereby

PHOSPHONOFORMIC ACID ESTERS

A compound of the formula, wherein R1, R2 and R3 are the same or different, and each is selected from the group consisting of hydrogen and phenyl groups of the formula, wherein R4 and R5 are the same or different and each is selected from the group consis

Synthesis of esters of phosphonoformic acid and their antiherpes activity

Aliphatic and aromatic mono-, di-, and triesters of phosphonoformic (foscarnet) were synthesized. The triesters were prepared by the Michaelis-Arbuzov reaction and were hydrolyzed to di- and monoesters. The compounds were tested for antiviral activity on isolated herpes simplex virus type 1 (HSV-1) DNA polymerase, in a HSV-1 plaque reduction assay, and on a cutaneous HSV-1 infection in guinea pigs. None of the esters inhibited the activity of isolated HSV-1 polymerases. Monoesters with a free carboxylic group and diesters with an aromatic carboxylic ester function were active against the cutaneous herpesa infection. Mono- and diesters with an aromatic phosphonic ester group also showed activity in the plaque-reduction assay. However, mono- and diesters with aliphatic carboxylic ester groups were inactive in all test systems. The results show that all three acidic groups of phosphonoformic acid must be free in order to get antiviral activity at the enzyme level. However, certain esters of this acid may be biotransformed to the acid itself to give antiherpes activity.