74274-71-8

Usage

InChI:InChI=1/C15H15FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h2,7-8,17H,1,3-6H2,(H,22,23)

Upstream product

• 87939-03-5 7-(4-Acetyl-piperazin-1-yl)-6-fluoro-1-(2-hydroxy-ethyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 75167-15-6 7-(4-ethoxycarbonyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid 
• 87939-15-9 ethyl 7-(4-acetyl-1-piperazinyl)-1-(2-chloroethyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 84233-60-3 ethyl 7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 87939-17-1 7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid 

Downstream Products

• 74274-72-9 6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-vinyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Pyridonecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent

The title compounds having nitro, amino, cyano, chloro, or fluoro as the C-6 substituent were prepared. Introduction of the chloro and cyano groups at C-6 was accomplished by the Sandmeyer reaction of 6-amino-1,8-naphthyridine derivatives via their 6-diaz

Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof

This invention relates to 1,8-naphthyridine compounds of the formula STR1 wherein X is a halogen atom especially fluorine atom, R1 is an ethyl group or a vinyl group, and R2 is a hydrogen atom or a lower alkyl group, their salts and processes for the preparation of them. The 1,8-naphthyridine compounds and their salts are useful as antibacterial agents and intermediates thereof.