74290-44-1

Usage

InChI:InChI=1/C45H73NO15/c1-13-34-32(23-48)19-25(4)14-15-33(50)26(5)20-31(16-17-47)41(27(6)35(57-30(9)49)21-37(52)58-34)61-44-40(53)39(46(11)12)42(28(7)56-44)60-38-22-45(10,54)43(29(8)55-38)59-36(51)18-24(2)3/h14-15,17,19,24,26-29,31-32,34-35,38-44,48,53-54H,13,16,18,20-23H2,1-12H3/b15-14+,25-19+

Upstream product

• 122825-66-5 2',3,4'''-tri-O-acetyl-4''-O-isovaleryltylosin 
• 122825-72-3 2',3-di-O-acetyl-4'''-deoxy-4''-O-isovaleryl-4'''-oxotylosin 
• 122825-73-4 2',3-di-O-acetyl-2''',3'''-didehydro-2'''-demethoxy-4'''-deoxy-4''-O-isovaleryl-4'''-oxotylosin 
• 105386-38-7 2',3-di-O-acetyl-4''-O-isovaleryltylosin 
• 122825-65-4 2',4'''-di-O-acetyl-4''-O-isovaleryltylosin 
• 63409-12-1 3-O-acetyl-4-O-isovaleryltylosin 
• 86031-95-0 2',4-di-O-acetyltylosin 
• 69988-46-1 2'-O-acetyltylosin 
• 1468-39-9 Isovaleric anhydride 
• 90577-41-6 2',3-di-O-acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin 

Relevant academic research and scientific papers

Semisynthetic Macrolide Antibacterials Derived from Tylosin. Synthesis of 3-O-Acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin and Related Compounds, as well as the 12,13-Epoxy Derivatives

Selective acylation techniques have been developed that enable the synthesis of 3-O-acetyl-4''-O-isovaleryltylosin and 3-O-acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin to be carried out in an efficient manner starting from tylosin.The syntheses of the 2'-O-acetyl, 23-O-acetyl, and 2',23-di-O-acetyl derivatives of the latter are also described.The synthesis of key hydrazones is also described.The regio- and stereo-selective epoxidation of tylosin and its acyl derivatives afforded the 12,13-epoxyanalogues, which were used to synthesize novel acylated 12,13-epoxy derivatives of 23-O-demycinosyltylosin.