90577-41-6

Upstream product

• 122825-72-3 2',3-di-O-acetyl-4'''-deoxy-4''-O-isovaleryl-4'''-oxotylosin 
• 122825-73-4 2',3-di-O-acetyl-2''',3'''-didehydro-2'''-demethoxy-4'''-deoxy-4''-O-isovaleryl-4'''-oxotylosin 

Downstream Products

• 122825-62-1 2',3-di-O-acetyl-23-O-demycinosyl-4''-O-isovaleryl-23-O-phenylacetyltylosin 
• 122825-77-8 C₅₇H₈₇N₃O₁₇S 
• 122825-63-2 3-O-acetyl-23-O-demycinosyl-4''-O-isovaleryl-23-O-phenylacetyltylosin 
• 74290-44-1 3-O-acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin 

Relevant academic research and scientific papers

Semisynthetic Macrolide Antibacterials Derived from Tylosin. Synthesis of 3-O-Acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin and Related Compounds, as well as the 12,13-Epoxy Derivatives

Selective acylation techniques have been developed that enable the synthesis of 3-O-acetyl-4''-O-isovaleryltylosin and 3-O-acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin to be carried out in an efficient manner starting from tylosin.The syntheses of the 2'-O-acetyl, 23-O-acetyl, and 2',23-di-O-acetyl derivatives of the latter are also described.The synthesis of key hydrazones is also described.The regio- and stereo-selective epoxidation of tylosin and its acyl derivatives afforded the 12,13-epoxyanalogues, which were used to synthesize novel acylated 12,13-epoxy derivatives of 23-O-demycinosyltylosin.