74290-66-7

Basic information

• Product Name: 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE
• Synonyms: 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE;3,5-DIBROMO-6-METHYLPYRAZIN-2-YLAMINE;3,5-DIBROMO-6-METHYLPYRAZIN-2-AMINE
• CAS NO: 74290-66-7
• Molecular Formula: C₅H₅Br₂N₃
• Molecular Weight: 266.9213
• Mol File: 74290-66-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 167-168 °C
• Boiling Point: 300.184 °C at 760 mmHg
• Flash Point: 135.347 °C
• Appearance: /
• Density: 2.105 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.661
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.11±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE(74290-66-7)
• EPA Substance Registry System: 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE(74290-66-7)

Safety Data

• Hazardous Substances Data: 74290-66-7(Hazardous Substances Data)

Usage

General Description

2-Amino-3,5-dibromo-6-methylpyrazine is a chemical compound belonging to the pyrazine family. It is a derivative of pyrazine with two bromine atoms and one methyl group attached to the pyrazine ring. 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE has potential applications in the pharmaceutical and agricultural industries as an intermediate for the synthesis of various biologically active compounds. It may also have use as a flavor and fragrance ingredient due to its aromatic properties. Additionally, 2-amino-3,5-dibromo-6-methylpyrazine is known for its strong and distinctive odor and is commonly used in the formulation of perfumes and other scented products.

InChI:InChI=1/C5H5Br2N3/c1-2-3(6)10-4(7)5(8)9-2/h1H3,(H2,8,9)

Upstream product

• 38557-71-0 2-chloro-6-methylpyrazine 
• 5521-56-2 6-methylpyrazin-2-amine 

Downstream Products

• 902135-42-6 3-benzyl-5-bromo-6-methylpyrazin-2-amine 
• 566204-89-5 N-(5-bromo-3-methoxy-6-methylpyrazin-2-yl)-2,3-dichlorobenzenesulfonamide 
• 902135-44-8 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine 
• 902135-43-7 3-benzyl-5-(4-benzyloxy)phenyl-6-methylpyrazin-2-amine 
• 5521-56-2 6-methylpyrazin-2-amine 

Relevant articles and documents

Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors

We report the discovery of a novel aminopyrazine series of PI3Kα inhibitors, designed by hybridizing two known scaffolds of PI3K inhibitors. We describe the progress achieved from the first compounds plagued with poor general kinase selectivity to compounds showing high selectivity for PI3Kα over PI3Kβ and excellent general kinase selectivity. This effort culminated with the identification of compound 5 displaying high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration. In vivo, compound 5 showed good inhibition of tumour growth (86% tumour growth inhibition at 50?mg/kg twice daily orally) in the MCF7 xenograft model in mice.

Compounds used as JAK inhibitor, and use of compounds

The invention provides compounds used as a JAK inhibitor, and a use of the compounds, and concretely provides compounds (represented by formula (I)) with JAK inhibition activity or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and a medicinal composition including the compounds. The invention also discloses a use of the compounds or the medicinal composition thereof in the preparation of medicines used for treating autoimmune diseases or proliferative diseases.

TREATMENT OF CHRONIC GRAFT VERSUS HOST DISEASE WITH SYK INHIBITORS

The present disclosure provides methods of utilizing Syk inhibiting compounds in the treatment for graft versus host disease (GVHD) in a human, including acute graft versus host disease (aGVHD) and chronic graft versus host disease (cGVHD), including the use of compounds selected from the group consisting of the formulas below: (I) and (II).