74339-45-0Relevant academic research and scientific papers
AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS
-
Paragraph 00162, (2019/03/17)
Provided herein are thiazole carboxamide protein secretin inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.
Cyclizations of unsymmetrical bis-1,2-(3-indolyl)ethanes: Synthesis of (-)-tjipanazole F1
Gilbert, Eric J.,Ziller, Joseph W.,Van Vranken, David L.
, p. 16553 - 16564 (2007/10/03)
The inter- and intramolecular dimerization of 3-substituted indoles was studied. The rate and extent of dimerization depends on the indole substituents. The intramolecular dimerization of unsymmetrical bis-1,2-(3-indolyl)ethanes could be controlled using either thermodynamic reaction conditions (neat trifluoroacetic acid) or kinetic conditions (2 equiv acid/chloroform). This control of regiochemistry has been applied to an efficient synthesis of (-)- tjipanazole F1.
