743430-90-2Relevant academic research and scientific papers
A new approach to isoindoloisoquinolinones. A simple synthesis of nuevamine
Moreau, Anne,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Lebrun, Stéphane
, p. 6169 - 6176 (2004)
A convenient and versatile short step synthesis of isoindoloisoquinolinones, illustrated by the total synthesis of the alkaloid nuevamine 1a, is described. The tetracyclic lactam compounds were obtained by a tactical combination of the Parham procedure for the elaboration of the isoindolinone template and an aryne-mediated cyclization giving rise to the nitrogen containing six-membered heteroring unit.
