743460-72-2Relevant academic research and scientific papers
Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules
Hughes, Adam D.,Chin, Kay H.,Dunham, Sarah L.,Jasper, Jeffrey R.,King, Kristin E.,Lee, Tae Weon,Mammen, Mathai,Martin, Jerri,Steinfeld, Tod
, p. 1354 - 1358 (2011/04/16)
We sought to design dual pharmacology bronchodilators targeting both the M3 muscarinic acetylcholine and beta-2 adrenergic (β2) receptors by applying our multivalent approach to drug discovery. Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.
